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Skip to Search Results- 1Arrieta Mendez, Marie Claire
- 1Backer, Jody Lynn
- 1Bai, Helin Daniel
- 1Déry, René
- 1Guo, Danny
- 1Lee, Thomas Wei Te
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Spring 2011
Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...
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Fall 2009
Inflammatory Bowel Diseases (IBD) result from the nexus of a genetic predisposition, dysregulated immunologic insult against commensal microflora, and an environmental trigger. The intestinal epithelium is a single cell layer that separates a highly active mucosal immune system from a large...
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Expression and functional significance of the cystic fibrosis transmembrane conductance regulator (CFTR) in human mast cells
DownloadFall 2009
Mast cells (MC) are present in nearly all tissues in the body and participate in many physiological processes including allergy, tissue remodelling, fibrosis, angiogenesis, and autoimmunity. They can be activated by many stimuli, including allergic and innate immune stimulation. When activated,...
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Molecular regulation and endogenous expression of CRTh2 in in vitro differentiated CRTh2+ Th2 cells
DownloadFall 2011
Allergic inflammation is mediated by T helper 2 (Th2) cells. Chemoattractant receptor homologous molecule expressed on Th2 cells (CRTh2) is expressed by Th2 cells and mediates chemotaxis and production of the Th2 cytokines interleukin (IL)-4, IL-5 and IL-13. To understand the molecular...
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Nuclear Magnetic Resonance metabolomic fingerprint of the Interleukin 10 gene deficient mouse model of Inflammatory Bowel Disease
DownloadFall 2010
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder that occurs as a consequence of a genetic mutation that results in an overly aggressive immune response to normal bacteria. Metabolomics is a new born cousin to genomics and proteomics and involves a high throughput...
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Fall 2010
Almost all mammalian cells contain energy-producing organelles called mitochondria. Phosphatidylethanolamine (PE) is a phospholipid which has been implicated to be important for mitochondrial function. The majority of mitochondrial PE is synthesized in mitochondria using the phosphatidylserine...
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Spring 2011
Nitric oxide (NO) is a short-lived free radical that plays a critical role in the regulation of cellular signalling. Mast cell (MC) derived NO and exogenous NO regulate MC activities including the inhibition of MC degranulation. At a molecular level the intermediate metabolites of NO modify...
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T cell-mediated inflammation is stereotyped: mouse delayed-type hypersensitivity reaction and mouse T cell-mediated rejection of renal allografts share common molecular mechanismsT cell-mediated inflammation is stereotyped
DownloadFall 2011
Genome-wide gene expression analysis of diseases has revealed large-scale changes in the expression of thousands of genes (transcripts) representing biological processes. The processes that occur during T cell-mediated rejection (TCMR) of renal allografts in mice and humans have been previously...
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Spring 2011
Abstract Objectives: To 1) develop an electronic Knowledge Model (e-KM) of a surgical procedure, and 2) investigate the efficacy of the model in knowledge acquisition. The main purpose of the study was to develop a knowledge model of a surgical procedure (cyst removal) in an electronic medium...
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The influence of iron therapy on the clinical outcomes, the colonic bacteria microbiome and the urinary metabolomics in iron deficient subjects
DownloadFall 2011
Iron deficiency is a common problem facing subjects with inflammatory bowel disease and it is of recurrent nature. It is associated with lethargy, fatigue and poorer cognition independent of anaemia. These symptoms could be reversed with iron supplementation either via oral or intravenous route....