The influence of iron therapy on the clinical outcomes, the colonic bacteria microbiome and the urinary metabolomics in iron deficient subjects

  • Author / Creator
    Lee, Thomas Wei Te
  • Iron deficiency is a common problem facing subjects with inflammatory bowel disease and it is of recurrent nature. It is associated with lethargy, fatigue and poorer cognition independent of anaemia. These symptoms could be reversed with iron supplementation either via oral or intravenous route. However, these two routes may have differential effects on the clinical outcomes such as quality of life and disease activity, the colonic bacterial microbiome composition and the urinary metabolomics. This thesis demonstrated that intravenous iron replacement was superior to oral iron replacement in improving the serum ferritin level and quality of life score. Moreover, compared to intravenous iron therapy, significant colonic bacterial dysbiosis was observed with oral iron therapy. The different urinary metabolite profiles between the two routes of iron therapy indicate the route of iron therapy had differential impact on the host’s and gut microbial metabolisms.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • Medicine
  • Supervisor / co-supervisor and their department(s)
    • Fedorak, Richard (Medicine)
  • Examining committee members and their departments
    • Fedorak, Richard (Medicine)
    • van Zanten, Sander (Medicine)
    • Ritchie, Bruce (Medicine)
    • Wine, Eytan (Paediatrics)