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Skip to Search Results- 2Sigalet, David L.
- 2Yamoah, Ebenezer Nketia.
- 1Aboelnazar, Nader Saber
- 1Abualhassan, Nasser
- 1Adegoke, Adeolu
- 1Aggarwal, Saloni
- 7Mesenchymal stem cells
- 7Scars
- 6Diabetes
- 6Islet transplantation
- 5Cerebrovascular spasm--Animal models
- 5Fibroblasts
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Fall 2013
Asphyxia is a significant cause of newborn morbidity and mortality. Multiorgan injury and dysfunction is a common finding, mediated in part through an increase in matrix metalloproteinase (MMP) activity. We hypothesized administration of doxycycline, a known MMP inhibitor, would improve systemic...
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Tolerance to neonatal porcine islet xenografts induced by a combination of monoclonal antibodies
DownloadFall 2009
Islet transplantation is a more physiological way to treat type 1 diabetes. However, shortage of donor tissue and chronic administration of immune suppressive drugs has limited the widespread application of this therapy for all patients with type 1 diabetes, particularly children suffering from...
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Spring 2018
Lung cancer has the highest mortality rates of all cancers worldwide, with a 5-year survival rate less than 15%. Screening methods are in need for the high risk population, as lung cancer is asymptomatic in its early stages. Proper screening methods would allow earlier diagnosis and curative...
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Fall 2015
The development of the Edmonton protocol was an important milestone in the process of establishing islet transplantation as a cure for diabetes. However, many challenges must still be overcome, including the shortage of donor organs. To address this issue, we believe that neonatal porcine islets...
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Trophic peptide therapies for neonatal short bowel syndrome: actions and mechanisms studied in a preclinical model
DownloadFall 2016
Short bowel syndrome (SBS) occurs when a significant length of intestine is surgically resected for both congenital and acquired intestinal abnormalities and remains a significant cause of morbidity and mortality in neonates. With an insufficient amount of intestine available for nutrient...
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Utilizing Positron Emission Tomography to Detect Functional Changes Following Drug Therapy in a Renal Cell Carcinoma Mouse Model
DownloadSpring 2013
Sunitinib is currently the first line drug therapy for metastasizing renal cell carcinoma (RCC). It has been shown to have a profound effect on tumor angiogenesis leading to modifications of the tumor’s microenvironment. Tumor hypoxia plays an important role in the metastatic potential of a solid...