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Skip to Search Results- 1Charrunchon, Sookpichaya
- 1Engel, Megan C
- 1Halma, Matthew
- 1Hoffer, Noel
- 1Rezajooei, Negar
- 1Soong, JingChyuan
- 3Biophysics
- 3Prion protein
- 2Energy landscape
- 2Force spectroscopy
- 2Optical Tweezers
- 2Optical tweezers
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Fall 2014
The structural dynamics of proteins and nucleic acids play a vital role in biochemical reactions. We employed novel optical tweezers to study the programmed -1 ribosomal frameshifting, where the conformational plasticity of a SARS pseudoknot with a bound ligand is shown to be correlated to the...
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Fall 2013
Protein folding involves a stochastic search through the configurational energy landscape towards the native structure. Although most proteins have evolved to fold efficiently into a unique native structure, misfolding (the formation of non-native structures) occurs frequently in vivo causing a...
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Spring 2017
Prion diseases, are associated with the misfolded form of the prion protein (PrPSc). The prion protein (PrP) has a unique means of transferring infectious diseases, based on a misfolded conformation. However, the mechanism of formation of PrPSc remains unclear owing to difficulties in defining...
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Fall 2021
Folding is the process by which biomolecules spontaneously self-assemble into specific, complex, three-dimensional structures from simple one-dimensional polypeptide chains. Folding is a critical process in biology as there exists a tight link between the structure and function of biomolecules,...
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Force spectroscopy of the frameshift signal from West Nile virus reveals multiple folding pathways and structural heterogeneity
DownloadSpring 2019
Programmed ribosomal frameshifting (PRF) represents an important mechanism for translational genetic recoding, especially in viruses. The components of a PRF stimulator have been well characterized, though accounting for the variation in the frameshift stimulating efficiency has thus far been...
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Fall 2013
For decades, scientists from every discipline have struggled to understand the mechanism of biological self-assembly, which allows proteins and nucleic acids to fold reliably into functional three-dimensional structures. Such an understanding may hold the key to eliminating diseases such as...
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Fall 2017
The formation of an abnormal form of proteins in cells can cause aggregation and neurodegenerative pathology, such as Alzheimer’s, Parkinson’s and prion diseases, which affects both humans and animals. Nowadays, the understanding of the mechanism of prion misfolding and propagation, including...