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Investigating the Conformational Dynamics of Biomolecules using Optical Tweezers

  • Author / Creator
    Soong, JingChyuan
  • The structural dynamics of proteins and nucleic acids play a vital role in biochemical reactions. We employed novel optical tweezers to study the programmed -1 ribosomal frameshifting, where the conformational plasticity of a SARS pseudoknot with a bound ligand is shown to be correlated to the frameshifting efficiency. We also investigated a mechanical model for components involved in optical tweezers, and tested their validity through a series of measurements.

  • Subjects / Keywords
  • Graduation date
    2014-11
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R39K46199
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Physics
  • Supervisor / co-supervisor and their department(s)
    • Woodside, Michael (Physics)
  • Examining committee members and their departments
    • LeBlanc, Lindsay (Physics)
    • Tuszynski, Jack (Physics)
    • Davis, John (Physics)