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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Logus, J. Wayne (John Wayne), 1951-
- 2Srivastava, Nutan
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 8Primary Biliary Cholangitis
- 7Inflammatory bowel disease
- 6Inflammatory Bowel Disease
- 5Acute myeloid leukemia
- 5Endothelial cells
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The Prion Protein: Modulation of Potassium Channels and a Novel Mouse Model of a Disease-Causing Hydrophobic Domain Insertion Mutation
DownloadSpring 2016
Mercer, Robert Corrigan Curtis
Prion diseases are invariably fatal neurodegenerative diseases of humans and other mammals. While they can manifest as sporadic, infectious or genetic etiologies, the central event in prion disease is the structural conversion of the prion protein (PrPC) to an alternative conformer PrPSc. PrP is...
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The prognosis and outcomes of patients with a ST-segment elevation myocardial infarction and the biochemical and clinical inflammatory response
DownloadSpring 2013
Acute myocardial infarction, and specifically coronary plaque rupture, has been associated with a systemic inflammatory cascade. Using multiple large clinical trial datasets, we sought to further understand the systemic and clinical inflammatory responses in patients with ST-elevation myocardial...
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THE PSYCHOSOCIAL FUNCTIONING OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE IN EARLY ADULTHOOD IS IMPAIRED
DownloadFall 2012
Inflammatory bowel disease is a chronic disease that is often diagnosed in childhood and adolescence. The objective of this study was to assess the impact of a diagnosis of IBD on the psychosocial functioning in early adulthood. This was a questionnaire-based cross-sectional study comparing...
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The Relationship (or Lack Thereof) Between Weight Loss and Health-Related Quality of Life in the Severely Obese
DownloadFall 2014
The impact of weight and weight loss on health-related quality of life (HRQL) in obese individuals and, in particular, the severely obese, is poorly understood. We completed a meta-analysis of published weight loss intervention trials; conducted cross-sectional analyses to examine...
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The Role of Community Completeness in Older Adults Experiences of Health and Wellbeing: A Photovoice Study
DownloadFall 2020
This thesis examines the role of community completeness in the health and wellbeing of older adults. Community completeness is a concept commonly used in urban planning policies by cities, however utilizations and definitions vary between locations. As the older adult population in Canada and...
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The role of endothelial PI3 kinase activity and IQGAP1 in regulation of lymphocyte diapedesis
DownloadFall 2011
Leukocyte extravasation is a fundamental process of the inflammatory responses. The mechanisms that control remodelling of endothelial (EC) shape and adhesive contacts during leukocyte transendothelial migration (TEM) are not completely understood. We studied the role of EC phosphatidylinositol...