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The Relationship (or Lack Thereof) Between Weight Loss and Health-Related Quality of Life in the Severely Obese

  • Author / Creator
    Warkentin, Lindsey M
  • The impact of weight and weight loss on health-related quality of life (HRQL) in obese individuals and, in particular, the severely obese, is poorly understood. We completed a meta-analysis of published weight loss intervention trials; conducted cross-sectional analyses to examine covariate-adjusted associations between weight and HRQL in 500 severely obese patients; and performed a 2-year longitudinal analysis to determine the weight-loss thresholds associated with clinically important HRQL improvements these patients. Previous literature showed modest physical HRQL improvement with weight loss and no mental HRQL improvement. In the cross-sectional analyses, HRQL was substantially impaired in the severely obese; however, body mass index was only modestly associated with impaired HRQL. Over two years, weight reductions of about 20% were predicted to be required to achieve clinically important HRQL improvements. Overall, we found minimal association between body mass and HRQL in the severely obese. Marked weight reductions are expected to be required to achieve clinically important HRQL improvement.

  • Subjects / Keywords
  • Graduation date
    2014-11
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R31V5BM3B
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Medicine
  • Specialization
    • Experimental Medicine
  • Supervisor / co-supervisor and their department(s)
    • Majumdar, Sumit (Medicine)
    • Padwal, Raj (Medicine)
  • Examining committee members and their departments
    • Twells, Laurie (Medicine)
    • Johnson, Jeff (School of Public Health)