The prognosis and outcomes of patients with a ST-segment elevation myocardial infarction and the biochemical and clinical inflammatory response

  • Author / Creator
    van Diepen, Sean
  • Acute myocardial infarction, and specifically coronary plaque rupture, has been associated with a systemic inflammatory cascade. Using multiple large clinical trial datasets, we sought to further understand the systemic and clinical inflammatory responses in patients with ST-elevation myocardial infarction (STEMI) and have three key findings. First, the systemic inflammatory response syndrome (SIRS) was associated with 90-day clinical outcomes. Second, interleukin (IL)-6 was modestly correlated with NT-proBNP suggesting that NT-proBNP may be expressed in response to systemic inflammatory stimuli. Third, although multiple inflammatory biomarkers independently predicted 90-day clinical outcomes, they added little value to a clinical prediction model that included N-terminal B-type natriuretic peptide (NT-proBNP). These findings reinforce the importance of the inflammatory response in STEMI in relation to both clinical outcomes and possible linkages to inflammatory biomarker expression and the natriuretic peptide system.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • Department of Medicine
  • Specialization
    • Experimental Medicine
  • Supervisor / co-supervisor and their department(s)
    • Ezekowitz, Justin A (Medicine)
  • Examining committee members and their departments
    • Ezekowitz, Justin A (Medicine)
    • Tsuyuki, Ross T (Medicine)
    • McAlister, Finlay A (Medicine)
    • Newby, L. Kristin (Medicine, Duke University)