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- 11,2-vinyl addition
- 12,5-anhydro-D-mannitol
- 1Capsular polysaccharide
- 1Carbon dioxide conversion and utilization
- 1Chemistry
- 2Todd L. Lowary
- 1Bozheng Sun, Meagan S. Oakley, Kota Yoshida, Yanwen Yang, Matteo Tommasini, Chiara Zanchi, Andrea Lucotti, Michael J. Ferguson, Frank Hampel, Mariusz Klobukowski, and Rik R. Tykwinski
- 1Chalifoux, Wesley A.
- 1Chu, Chun-Jui
- 1Johnson, Matthew A.
- 1Kirk, Bryce J.
- 6Graduate and Postdoctoral Studies (GPS), Faculty of
- 6Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 4Chemistry, Department of
- 4Chemistry, Department of/Journal Articles (Chemistry)
- 1Concordia University of Edmonton
- 1Concordia University of Edmonton/Student Research Forum (Concordia University of Edmonton)
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2019-01-31
Sicheng Lin, Roger Ashmus, Todd L Lowary
A route for the synthesis of glycuronamides via the intermediacy of 6-S-tolyl-glycosides and uronic acid thioesters, is reported. The route, which is compatible with a variety of carbohydrate residues and protecting groups, was used to synthesize the repeating unit of the E. coli K54 capsular...
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Engineering Gene Vectors: Synthesis of Thioether-Lipid Polyethyleneimine Conjugates for pDNA and siRNA Delivery
DownloadFall 2024
Gene therapy offers a promising approach for treatment of a diverse array of diseases at their genetic root causes. The cationic polyethyleneimine (PEI) has been extensively used for successful non-viral nucleic acid delivery in experimental systems, but its clinical utility has been hampered by...
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New abundant 4CzIPN-derivatized Photosensitizers and Catalysts for Photosynthetic Organic Reactions and Solar Fuels
DownloadSpring 2024
The development of artificial photosynthetic systems is a promising strategy to meet future energy demands of our society and to reverse the impact of anthropogenic CO2 in the environment. Energy conversion devices such as photoelectrochemical cells are one key component in the transition to a...
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Spring 2020
Polycyclic aromatic hydrocarbons (PAHs), or more specifically pentacene derivatives, are promising candidates for solar energy conversion. Pentacenes can undergo π-stacking in solution and, consequently, can be poorly soluble. Furthermore, the pentacene moiety can react with oxygen, and it can...
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Fall 2017
Glycans play essential roles in the life cycle of bacteria and often modulate interactions with their environment. Chemical synthesis provides a useful tool to access structurally well-defined bacterial glycans. These molecules can serve as probes for elucidating the biological function of these...
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Synthesis of a homologous series of galactofuranose-containing mycobacterial arabinogalactan fragments
Download2019-01-31
Mycobacteria, including the human pathogen Mycobacterium tuberculosis the causative agent of tuberculosis, produce a complex cell wall structure made of carbohydrates and lipids. The major structural element of the mycobacterial cell wall is a glycoconjugate called the mycolic...
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Spring 2020
“To understand something” is a perpetual theme in scientific research. In carbohydrate chemistry, we pursue to understand certain properties of sugar molecules. This is further described as the purpose of my research “understanding Mycobacterium marinum lipooligosaccharides’ (LOSs) immnuogenic...
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2021-04-16
Hepta-1,3,6-trien-5-ols have the potential to act as electrocyclization precursors in anionic 7 carbon/8π conrotatory transformations. A concise synthesis of these trienol substrates is discussed. The sequence of Vilsmeier Haack type reaction, 1,2-vinyl addition, and a Suzuki-Miyaura...
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Synthesis of the Campylobacter jejuni 81-176 strain capsular polysaccharide repeating unit reveals the absolute configuration of its O-methyl phosphoramidate motif
Download2019-01-30
V. Narasimharao Thota, Michael J. Ferguson, Ryan P. Sweeney, Todd L. Lowary
The O-methyl phosphoramidate (MeOPN) motif is a non-stoichiometric modification of capsular polysaccharides (CPS) in ~70% of all Campylobacter jejuni strains. Infections by C. jejuni lead to food-borne illnesses and the CPS they produce are key virulence factors. The MeOPN phosphorus atom in...