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Synthesis of Hepta-1,3,6-trien-5-ols for potential 8π electrocyclizations
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- Author(s) / Creator(s)
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Hepta-1,3,6-trien-5-ols have the potential to act as electrocyclization precursors in anionic 7 carbon/8π conrotatory transformations. A concise synthesis of these trienol substrates is discussed. The sequence of Vilsmeier Haack type reaction, 1,2-vinyl addition, and a Suzuki-Miyaura cross-coupling allows for multiple points of elaboration and alkenyl stereocontrol. Finally, the alcohol can be converted to groups such as silyl ethers or carbamates to probe the impact on carbolithiation.
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- Date created
- 2021-04-16
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- Subjects / Keywords
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- Type of Item
- Conference/Workshop Poster