Search
Skip to Search Results- 1Ahmed, Kazi Tanveer
- 1Aroonassala Patten, Shunmoogum
- 1Brewster, Daniel L
- 1Cheng, Caroline ST
- 1Cunningham, Marcus E
- 1Drummond, Danna L
-
Spring 2012
The escape response in zebrafish is mediated in part by the Mauthner cell and its two homologues, MiD2cm and MiD3cm. In adult fish, the Mauthner cell fires a single action potential when activated while the homologues fire multiple action potentials. Their distinct firing properties are partially...
-
Identification and Molecular Characterization of Zebrafish (Danio rerio) Leukocyte Immune-Type Receptors (DrLITRs)
DownloadSpring 2020
In response to foreign invaders, innate immune cells use cell surface-expressed receptors to trigger intracellular signalling cascades that control various effector responses designed to destroy microbes. These specialized receptors are known as immunoregulatory receptors and structurally they...
-
Transcriptional regulation of the zebrafish activation-induced cytidine deaminase (AID) gene
DownloadFall 2012
Activation-induced cytidine deaminase (AID, encoded by Aicda) mediates affinity maturation of immunoglobulin genes. Early studies in mammals indicated that the transcription of Aicda was regulated by a number of transcriptional regulatory regions, including a B-cell specific enhancer in the...
-
Interactions between Amyloid Precursor Protein and Prion Protein Impact Cell Adhesion and Apoptosis in the Developing Zebrafish
DownloadFall 2011
We report here that knockdown of either amyloid precursor protein (APP) or prion protein (PrP) in the zebrafish produces an overt dose-dependent phenotype characterized by systemic morphological defects and CNS cell death. We report findings that the zebrafish PrP-1 gene genetically interacts...
-
Differential expression of nicotinic acetylcholine receptor subunits is critical for the embryonic development of zebrafish muscle and neuromuscular junction
DownloadSpring 2020
Nicotinic acetylcholine receptors (nAChRs) are ligand gated ion channels primarily expressed on muscle fibers and neurons. They are comprised of five subunits arranged in different stoichiometries. nAChRs expressed at the neurons are comprised of different combinations of α1-10 and β1-4 subunits,...
-
Zebrafish embryos exposed to alcohol undergo abnormal development of motor neurons and muscle fibers
DownloadFall 2009
Children with Fetal Alcohol Spectrum Disorder have significantly delayed motor skills, and deficiencies in reflex development. The reasons underlying these motor deficits are not fully understood. The purpose of this thesis was to investigate the effect of embryonic exposure to ethanol (EtOH) on...
-
Spring 2010
Development of the vertebrate central nervous system is a complex process that relies on the accurate spatiotemporal distribution of signaling centers during embryogenesis. These signals provide cells with positional information, which is integrated via transcription factors and gene regulatory...
-
Zic transcription factors regulate retinoic acid metabolism during zebrafish neural development
DownloadSpring 2012
Retinoic acid (RA) has a crucial role in embryonic nervous system development - controlling anterior-posterior patterning, neural differentiation, and cell proliferation. During zebrafish embryogenesis, levels of RA are tightly regulated by the combinatorial action of synthesis and degradation...
-
Functional Characterization of Homeodomain Transcription Factors and Retinoic Acid Signaling in Hematopoiesis
DownloadSpring 2015
Improper regulation of hematopoiesis generates a spectrum of defects that range from anemia and embryonic lethality to leukemia. Identifying the molecular pathways that regulate hematopoiesis is therefore a major goal of both basic and clinical biology. Vertebrate hematopoiesis occurs in two...