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- 3Field, Catherine J.
- 2Ametaj, Burim N.
- 2Dervishi, Elda
- 2Hailemariam, Dagnachew
- 2Proctor, Spencer D.
- 2Ruth, Megan R.
- 16Graduate Studies and Research, Faculty of
- 16Graduate Studies and Research, Faculty of/Theses and Dissertations
- 9Agricultural, Food and Nutritional Science, Department of
- 9Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Biological Sciences, Department of
- 2Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 4Department of Medical Microbiology and Immunology
- 4Department of Surgery
- 2Department of Medicine
- 1Department of Cell Biology
- 1Department of Chemical and Materials Engineering
- 1Department of Immunology
Dynamic Changes of Monocytes and Chemokine Pathway Signaling During Wound Healing Post-Burn InjuryDownload
Background:There are over 11 million people hospitalized for burns annually according to the World Health Organization, resulting in painful skin scar contractures and restricted movements, as well as mental and physical stresses. Up to 70% of deep dermal injury result in hypertrophic scars,...
Poxviruses encode many genes that are orthologs of cellular genes. These orthologs serve many functions, but those that are of most interest are ones that have evolved further and now serve an immune-evasion function. Such genes were likely first acquired by poxviruses through some form of...
Respiratory syncytial virus (RSV) is a ubiquitous respiratory pathogen that infects almost everyone by the age of two. In high-risk populations, such as infants and elderly individuals, RSV can infect the lower respiratory tract and cause severe symptoms, such as bronchiolitis or pneumonia. As a...
Infectious respiratory diseases, caused by viruses and bacteria that attack the respiratory system, constitute a serious threat in public health around the world. Pathogens can be transmitted in the air though large droplets or aerosols. As aerosols can linger in the environment for a prolonged...
Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infectionDownload
Van Goor, Angelica, Pasternak, Alex, Walker, Kristen, Hong, Linjun, Malgarin, Carolina, MacPhee, Daniel J., Harding, John C. S., Lunney, Joan K.
Background:A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the maternal-fetal-interface resulting in varying disease outcomes. However,the mechanisms leading to variation in fetal outcome in response to PRRSV...
Inhibition and enhancement of Respiratory Syncytial Virus replication by nucleoside analogues and bis(indole) compoundsDownload
Respiratory syncytial virus (RSV) is an Orthopneumovirus that infects the epithelium of the airways. Severe RSV infection of the lower respiratory tract in infants is a leading cause of pediatric hospitalizations. RSV also causes substantial morbidity in immunocompromised and elderly populations....
Small intestine early innate immunity response during intestinal colonization by Escherichia coli depends on its extra-intestinal virulence statusDownload
Denamur, Erick, Tourret, Jérôme, Dion, Sara, Willing, Benjamin P., Wachtel, Sarah, Finlay, B. Brett, Dufour, Nicolas, Croxen, Matthew A.
Uropathogenic Escherichia coli (UPEC) strains live as commensals in the digestive tract of the host, but they can also initiate urinary tract infections. The aim of this work was to determine how a host detects the presence of a new UPEC strain in the digestive tract. Mice were orally challenged...
Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphateDownload
Zhao, Yuan Y., McMullen,Todd P. W. , Brindley, David N., Curtis, Jonathan M., Benesch, Matthew G. K.
Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is also involved in wound healing and...
Innate immunity and carbohydrate metabolism alterations precede occurrence of subclinical mastitis in transition dairy cowsDownload
Dervishi, Elda, Dunn, Suzana M., Zhang, Guanshi, Ametaj, Burim N., Hailemariam, Dagnachew
Background This study examined whether activation of innate immunity and alterations of carbohydrate and lipid metabolism precede development of subclinical mastitis (SCM). Methods Blood samples were collected from the coccygeal vein from 100 Holstein dairy cows at -8, -4, disease diagnosis week,...
Alterations of innate immunity reactants in transition dairy cows before clinical signs of lamenessDownload
Dervishi, Elda, Hailemariam, Dagnachew, Zhang, Guanshi, Goldansaz, Seyed A., Deng, Qilan, Dunn, Suzanna M., Ametaj, Burim N.
The objectives of this study were to evaluate metabolic and innate immunity alterations in the blood of transition dairy cows before, during, and after diagnosis of lameness during periparturient period. Blood samples were collected from the coccygeal vain once per week before morning feeding...