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Spring 2024
Background: The Human Microbiome is an area of increasing interest, both in and outside of the scientific community. While overall knowledge has increased exponentially, many aspects remain unclear, such as mechanisms of host-interaction and persistence. Intracellular bacteria have previously...
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Development of Liquid Chromatography Mass Spectrometry Methods for the Identification and Quantification of Acylcarnitines in Biological Samples
DownloadFall 2012
The field of metabolomics follows the Greek premise where metabolic changes are believed to be indicative of disease. Acylcarnitines, for example, can be dysregulated in the presence of various diseases including genetic metabolic disorders and multiple sclerosis. Liquid chromatography mass...
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Evaluating the Role of Bacterial Lipopolysaccharide on Etiology and Pathogenesis of Transmissible Spongiform Encephalopathies
DownloadFall 2014
Transmissible spongiform encephalopathies (TSEs) or otherwise known as prion diseases are a class of fatal neurodegenerative diseases related to irreversible brain damage. Presently, there is no effective treatment or preventive strategy for this disease because the etiology and biological...
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Putative ante-mortem indicators of Alzheimer’s dementia: Analysis of fluid biomarker and neuroimaging studies
DownloadSpring 2019
Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...
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Fall 2012
Pancreatic cancer is a leading cause of cancer-related death, due to its aggressive biology, lack of tools for early diagnosis and screening, advanced presentation and resistance to adjuvant therapy. Metabolomics, the newest of the “omics” sciences, may offer the potential for non-invasive...