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Urinary Metabolomic Signature of Pancreatic Ductal Adenocarcinoma

  • Author / Creator
    Davis, Vanessa W
  • Pancreatic cancer is a leading cause of cancer-related death, due to its aggressive biology, lack of tools for early diagnosis and screening, advanced presentation and resistance to adjuvant therapy. Metabolomics, the newest of the “omics” sciences, may offer the potential for non-invasive screening of early tumor associated perturbations in cellular metabolism. We applied metabolomic techniques as a potential discriminating tool in the diagnosis of early stage and locally advanced pancreatic cancer. Urinary nuclear magnetic resonance spectroscopic analysis of pancreatic ductal adenocarcinoma was associated with a distinct metabolomics signature, was detectable in both early stage and locally advanced disease when compared with healthy, age and gender matched controls and was extinguished following complete, R0 surgical resection. These preliminary results suggest that metabolomics approaches may facilitate discovery of novel biomarkers capable of early disease detection.

  • Subjects / Keywords
  • Graduation date
    2012-11
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R35D1X
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • School Public Health Sciences
  • Supervisor / co-supervisor and their department(s)
    • Sawer, Michael B (Department of Medical Oncology)
    • Schiller, Daniel E (Department of Surgery)
    • Eurich, Dean (Public Health Sciences)
  • Examining committee members and their departments
    • Sawyer, Michael B (Department of Medical Oncology)
    • Eurich, Dean (Public Health Sciences)
    • Schiller, Daniel E (Department of Surgery)
    • Bigam, David (Department of Surgery)