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- 11Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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- 2Chemistry, Department of/Journal Articles (Chemistry)
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Fall 2011
The pradimicins are natural products that are both structurally intriguing to a synthetic chemist and possess biological activity as antifungal and antiviral agents. Our interest towards designing a synthetic route for these compounds and various analogues was sparked by the potential to produce...
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Synthetic Polyprenol-Pyrophosphate Linked Oligosaccharides Are Efficient Substrates for Mycobacterial Galactan Biosynthetic Enzymes
Download2019-01-31
Xiaochao Xue, Ruixiang Blake Zheng, Akihiko Koizumi, Ling Han, John S. Klassen, Todd L. Lowary
Mycobacteria, including the human pathogen Mycobacterium tuberculosis, produce a complex cell wall that is critical for their survival. The largest structural component of the cell wall, the mycolylarabinogalactanpeptidoglycan complex, has at its core a galactan domain composed of...
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The Synthesis of and Methodology for Archipelago Model Asphaltenes with a Benzo[b]anthraquinoline Core
DownloadFall 2013
The efficient synthesis of model asphaltenes as polyaromatic, nitrogenous compounds is reported. These model asphaltenes are to be used for supramolecular investigation for developing enhanced bitumen processing methodology. Our synthesis of benzo[f]quinoline and benzo[b]anthraquinoline...
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Spring 2014
Fluorous phase chemistry is an emerging field in terms of new separation techniques. A highly fluorinated compound tends to dissolve in a fluorinated solvent rather than in a common organic solvent. Fluorophilic solid phase separation (F-SPE) techniques are also well established. Our goal is to...
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Tuning π-Conjugated Polymers with Heteroatoms: Synthesis of Polytellurophenes and Soluble Polyacetylenes
DownloadFall 2021
This Thesis describes the synthesis and investigation of π-conjugated oligomers and polymers with optoelectronic properties affected by the presence of a heteroatom. Two major classes of polymers are discussed: 1) polytellurophenes, where the backbone is formed by 5-membered heterocycles...
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2020-01-01
SSHRC Knowledge Synthesis grant awarded 2020. Main objectives of research are to (i) critically assess the state of the knowledge, (ii) identify the effective interventions on reducing transportation generated air pollution, (iii) examine the scientific methodologies and metrics used to identify...