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Skip to Search Results- 1Aktary, Zackie M
- 1Alenazi, Abdulrahman, F
- 1Alyenbaawi, Hadeel Eb
- 1Arnold, Tamara D.
- 1Barakat, Khaled H.
- 1Basonbul, Asmaa A.
- 2Department of Physics
- 1Department of Biochemistry
- 1Department of Cell Biology
- 1Department of Medicine
- 1Department of Oncology
- 1Department of Surgery
- 1Berthiaume, Luc (Cell biology)
- 1Brandwein, Joseph (Medicine)
- 1Dr. Charles F.B. Holmes, Department of Biochemistry
- 1Dr. Hadi Seikaly, Division of Otolaryngology, Department of Surgery
- 1Dr. Vincent Biron, Division of Otolaryngology, Department of Surgery
- 1Hugh, Judith (Laboratory Medicine and Pathology)
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Computational High Throughput Screening Targeting DNA Repair Proteins To Improve Cancer Therapy
DownloadSpring 2012
Developing a new drug is a complex, highly structured, and expensive task. The further a potential drug progresses in the development process, the more costly its failure becomes. Virtual screening (VS) is the initial stage of a drug discovery process. Its job is to screen large compound...
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Development of Genetic Medicines for the Treatment and Prevention of Infectious Disease, Cancer, and Aging
DownloadSpring 2022
Gene therapy has potential to become the Holy Grail of modern medicine, however, its clinical success has been hindered due to the lack of a safe and effective nucleic acid delivery platform. The recent success of non-viral RNA delivery platforms has revitalized the field and spurred great...
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Evaluation of Targeted Selective Inhibitors to Enhance Temozolomide Treatment Sensitivity in Acute Myeloid Leukemia
DownloadSpring 2024
Temozolomide (TMZ) is an alkylating agent with limited activity in acute myeloid leukemia (AML). The DNA repair enzyme O6-methylguanine methyltransferase (MGMT) enhances tumor cell resistance to TMZ. B-cell lymphoma-2 (BCL-2) and mouse double minute 2 homology (MDM2) are proteins involved in AML...
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Fall 2013
Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin with similar dual adhesive and signaling functions. The adhesive function of these proteins is mediated by their interactions with cadherins and their signaling function by association with various...
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Molecular Mechanisms Underlying the Regulation of Protein Phosphatase-1c by the Apoptotic Stimulating Proteins of p53
DownloadFall 2013
Protein phosphatase-1c (PP-1c) is a ubiquitous serine/threonine protein phosphatase regulated in part by association with a large number of different regulatory subunits. Apoptotic Stimulating Proteins of p53 (ASPPs) are a family of proteins that regulate the apoptotic function of the tumour...
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Molecular Prognostication of Oral Cavity Squamous Cell Carcinoma by Tissue Microarray Analysis
DownloadSpring 2018
AimsOral cavity squamous cell carcinoma (OCSCC) is a molecularly heterogeneous disease, which is thought to account for differences in treatment response between patients who have otherwise similar characteristics. Cancer biomarkers provide a means of molecular classification, which can be of...
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Fall 2012
The protein p53 is a key regulator of cellular response to a wide variety of stresses. In cancerous cells inhibitory regulators of the p53 protein such as MDM2 and MDMX are often overexpressed. In silico techniques could be used to inform the selection of interactions to target with novel drug...
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The Regulation of p53 by E3 ligases MDM2 and CHIP in Breast Cancer: Analysis of the Role of Hsp70 and Hsp90
DownloadSpring 2016
Tumor suppressor p53 is commonly mutated in breast cancer. Mutant p53 protein is highly stable and oncogenic. This study aims to understand the underlying mechanism of the regulation and stabilization of mutant p53 protein particularly folded mutant p53 R280K. The data showed a possible...