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- 4Chakrabarti, Subhadeep
- 4Klassen, John S.
- 4Liu, Lan
- 4Lowary, Todd L.
- 3Majumder, Kaustav
- 23Graduate and Postdoctoral Studies (GPS), Faculty of
- 23Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 11Agricultural, Food and Nutritional Science, Department of
- 11Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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- 4Chemistry, Department of/Journal Articles (Chemistry)
- 5Department of Agricultural, Food, and Nutritional Science
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- 1Department of Agricultural, Food and Nutritional Science
- 2Proctor, Spencer (AFNS)
- 1Baker, Glen (Psychiatry)
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- 1Curtis, Jonathan (Agricultural, Food and Nutritional Science)
- 1Curtis, Jonathan (Department of Agricultural, Food and Nutritional Science)
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Molecular targets of antihypertensive peptides: Understanding the mechanisms of action based on the pathophysiology of hypertension
Download2015
Majumder, Kaustav, Wu, Jianping
There is growing interest in using functional foods or nutraceuticals for the prevention and treatment of hypertension or high blood pressure. Although numerous preventive and therapeutic pharmacological interventions are available on the market, unfortunately, many patients still suffer from...
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Non-fasting remnant cholesterol as a predictor for cardiovascular disease risk in Canadians with and without diabetes mellitus in the Alberta’s Tomorrow Project
DownloadFall 2022
Cardiovascular disease (CVD) is a leading cause of death in Canada, and its risk of development is 3 times greater in those with diabetes mellitus (DM). Fasting low-density lipoprotein cholesterol (LDL-C) is the traditional lipid biomarker used in CVD risk assessment. While lowering LDL-C does...
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Notch regulates the growth-promoting nitric oxide cGMP-dependent pathway in epithelial ovarian cancer and ovarian surface epithelium cells
DownloadSpring 2014
El-Sehemy, Ahmed Ali Ahmed Ali
Ovarian cancer is the leading cause of mortality among gynecologic cancers. There are several subtypes of ovarian cancer, amongst which epithelial ovarian cancer (EOC) makes up to 90% of all ovarian cancers. The current treatment for EOC consists of debulking surgery followed by a...
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NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health Authorities
DownloadSpring 2012
The objective of this work was to synthesize and evaluate the biological properties of a new series of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol linker between the carboxylic acid present in classical NSAIDs and a NO-releasing group (PROLI/NO)...
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Nutritional Factors Impacting Intestinal Lipid Metabolism Using a Model of Low Birth Weight Swine
DownloadSpring 2018
Introduction: Non-communicable diseases (NCDs) such as obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) are increasing at an alarming rate globally. A common feature in these conditions is increased adiposity leading to insulin resistance (IR). Dyslipidemia is a major contributing...
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Polymer-Based Nanodiscs for Structural and Functional Analyses of Bacterial and Mammalian Membrane Proteins
DownloadSpring 2020
Unlike cytosolic proteins, membrane proteins (MPs) are embedded within the plasma membrane and the lipid bilayer of intracellular organelles. MPs serve in various cellular processes such as ion and metabolite transports, bioenergetic processes, signal transductions, and cell-cell communications....
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2005
van Houten, B., Patel, M., Chan, C. B., Orrenius, S. , Fariss, M. W.
Oxidative stress and mitochondrial oxidative damage have been implicated in the etiology of numerous common diseases. The critical mitochondrial events responsible for oxidative stress–mediated cell death (toxic oxidative stress), however, have yet to be defined. Several oxidative events...
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Fall 2017
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
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Structure and stability of carbohydrate-lipid interactions: Methylmannose polysaccharide-fatty acid complexes
Download2016
Klassen, John S., Siuda, Iwona, Renaud, Justin, Tieleman, D. Peter, Kitova, Elena N., Liu, Lan, Mayer, Paul M., Richards, Michele R., Lowary, Todd L.
We report a detailed study of the structure and stability of carbohydrate–lipid interactions. Complexes of a methylmannose polysaccharide (MMP) derivative and fatty acids (FAs) served as model systems. The dependence of solution affinities and gas-phase dissociation activation energies (Ea) on FA...