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Skip to Search Results- 7Islet transplantation
- 6Xenotransplantation
- 3Diabetes
- 3Neonatal porcine islets
- 2Mesenchymal stem cells
- 2Neonatal Porcine Islets
- 1Abualhassan, Nasser
- 1Akbari Motlagh, Roozbeh
- 1Arefanian, Hossein
- 1Bayrack, Kevin R
- 1Ellis, Cara E
- 1Hayward, Julie A
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Fall 2017
Mesenchymal stem cells (MSCs) have immuno-regulatory, anti-inflammatory, and pro-angiogenic properties through the secretion of a myriad of trophic factors, and have been shown to have a beneficial effect on graft function. In this thesis we investigated whether MSCs’ have an effect on neonatal...
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Fall 2011
Islet transplantation is promising treatment for certain patients with type 1 diabetes who experience recurrent episodes of hypoglycemia with unawareness. One opportunity to improve on islet transplant outcomes and potentially broaden the recipient population, is to reduce the early post...
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Evaluation of the Protection Induced by a Monotherapy of Anti-LFA-1 Monoclonal Antibody and Co-transplantation of Neonatal Porcine Islets with Sertoli Cells
DownloadSpring 2012
Two major barriers to islet transplantation are the need for an unlimited source of donor tissue and a safer method of immunosuppression. These may be overcome by xenotransplantation of neonatal porcine islets (NPI) along with combined co-transplantation of neonatal porcine Sertoli cells (SC)...
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Improving Techniques for Cell Implantation and their Impact on Managing Diseases of the Pancreas
DownloadFall 2016
The use of experimental animals early in the twentieth century has revolutionized medicine and significantly improved our understanding of disease processes. The ability to reproduce a medical condition in a mouse model has provided great insights into the cellular and molecular biology of the...
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Fall 2019
Diabetes is a chronic metabolic condition characterized by hyperglycemia resulting from impaired glucose metabolism. Type 1 diabetes mellitus (T1DM) is a result of progressive autoimmune destruction of insulin-producing pancreatic beta (β)-cells. By far, parenteral insulin replacement is...
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Fall 2009
Islet transplantation has the potential to be an effective treatment for patients with type 1 diabetes. However, a shortage of human donor islets and the need for continuous immunosuppressive therapy currently limit this therapy to patients with brittle type 1 diabetes. Neonatal pigs may...
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Spring 2013
Type 1 diabetes mellitus (T1DM) is a chronic disorder of glucose metabolism due to autoimmune destruction of insulin producing β-cells. Although insulin therapy is the standard treatment for T1DM, islet transplantation, which has emerged as an alternative to insulin injection, offers a more...
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Fall 2023
Islet transplantation can achieve insulin independence in individuals with type 1 diabetes. However, islets derived from multiple donors are often required, and functional β-cells are lost early after transplantation. Notably, up to 80% of newly transplanted islets are lost due to cell death...
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The potential of novel small inhibitory molecules to prevent the rejection of neonatal porcine islets in mice
DownloadFall 2011
The objectives of this study were to determine the effect of small inhibitory molecules suramin and DR80 on T cell proliferation in vitro as well as in vivo by preventing the rejection of neonatal porcine islets (NPI) in mice when combined with anti-LFA-1 monoclonal antibody (mAb). Suramin and...
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Tolerance to neonatal porcine islet xenografts induced by a combination of monoclonal antibodies
DownloadFall 2009
Islet transplantation is a more physiological way to treat type 1 diabetes. However, shortage of donor tissue and chronic administration of immune suppressive drugs has limited the widespread application of this therapy for all patients with type 1 diabetes, particularly children suffering from...