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Skip to Search Results- 3Serpe, Michael J.
- 2Gao, Yongfeng
- 2Ullah, Aman
- 1Abbasi Dezfouli, Meysam
- 1Ahiabu, Andrews
- 1Akin, Oguz
- 44Graduate and Postdoctoral Studies (GPS), Faculty of
- 44Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 5Chemistry, Department of
- 4Chemistry, Department of/Journal Articles (Chemistry)
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- 2WISEST Summer Research Program/WISEST Research Posters
- 11Department of Chemical and Materials Engineering
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- 2Choi, Phillip (Chemical and Materials Engineering)
- 2Evans, David (Medical Microbiology and Immunology)
- 2Hitt, Mary (Oncology)
- 2Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2Temelli, Feral (Agricultural, Food and Nutritional Science)
- 1Acker, Jason (Laboratory Medicine and Pathology)
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Spring 2021
Vaccinia virus (VACV) has shown promise as an oncolytic agent for treating a variety of tumour types, with preliminary results suggesting that this strategy holds promise for treating breast cancer. Our lab has previously modified VACV by deleting virally-encoded enzymes responsible for dNTP...
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Fall 2016
Synthetic polymers are still widely used in today’s life despite all environmental issues attributed to them. Replacing synthetic polymers with natural biodegradable polymers has been considered as a way of reducing these environmental impacts partially, if not completely. Hydroxyporpyl xylan...
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Investigating Radiation in Combination with Oncolytic Vaccinia Virus to Improve the Treatment of Glioblastoma
DownloadFall 2023
Glioblastoma (GBM) is a malignant and immune-suppressed brain cancer that remains incurable despite the current standard of care. Radiotherapy is a mainstay of GBM treatment, however invasive cancer cells outside the irradiated field and radioresistance preclude complete eradication of GBM cells....
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Investigation Using Polymer Additives to Mitigate Erosion in Multiphase Turbulent Pipe Flow
DownloadSpring 2019
Long chained polymers were evaluated for their impact on reducing pipe erosion during two-phase flow. The research study was compartmentalized into three categories. One of the components of this study investigated the erosion of different materials in an attempt to find a faster eroding...
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Lipid Modified Polymers for Transfection of Human CRL Fibroblasts, and for siRNA Mediated MDR Reversal in Melanoma Cancer Therapy
DownloadFall 2010
Gene delivery for therapeutic purposes is quickly emerging as the best potential treatment option for inherited genetic diseases and cancer. Viral gene carriers have been the choice for this purpose due to their high efficiency, but harmful immunogenic and oncogenic host reactions have limited...
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Liposome-based therapy: An alternative approach to treat Helicobacter pylori infection in high prevalence communities such as Aklavik, NWT
DownloadSpring 2016
Helicobacter pylori infects about half of the world population causing chronic gastritis, peptic ulcer or gastric cancer. The Aboriginal people in Aklavik, NWT, Canada are concerned about gastric cancer because of the high prevalence of H. pylori infection (58%) in their community. H. pylori...
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1996
Abstract: Macrophages play an important role in the immunopathogenesis of AIDS, The objective of this study was to investigate the possibility of specific targeting of antivirals such as azidothymidine (AZT) to macrophages, using nanoparticles as a colloidal drug carrier, The body distribution of...
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Fall 2015
Caverhill-Godkewitsch, Saul A.
The infrastructure necessary to support diagnostic and pathogen-detection processes does not exist in some regions of the world that need it most. Access to fast, inexpensive and portable diagnostic infrastructure could be a solution to this problem. Next generation lab-on-chip (LOC) systems that...
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Novel Agents Inhibiting Hepatitis C Virus; Application to Prevention of Re-infection after Liver Transplantation
DownloadFall 2013
Recurrent Hepatitis C virus infection drives inferior outcomes experienced by patients undergoing liver transplantation due to HCV-associated liver disease. Existing therapies exhibit increased toxicity, poor efficacy, and profound patient intolerability in the immediate transplantation period....
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Spring 2017
Oilsands tailings are a waste product comprising primarily a stable alkaline suspension of clay in water. This waste product of oilsands mining is environmentally hazardous to store and expensive to safely dispose of. This work presents two novel ideas for dealing with the waste. The first is...