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Macrophage Targeting of Azidothymidine: A Promising Strategy for AIDS Therapy

  • Author(s) / Creator(s)
  • Abstract: Macrophages play an important role in the immunopathogenesis of AIDS, The objective of this study was to investigate the possibility of specific targeting of antivirals such as azidothymidine (AZT) to macrophages, using nanoparticles as a colloidal drug carrier, The body distribution of AZT bound to nanoparticles and as a control solution was studied in rats after intravenous and peroral administration, C-14-Labeled AZT was bound to nanoparticles in the presence of bis(2-ethylhexyl)sulfosuccinate sodium, The radioactivity was measured in different organs including those containing large numbers of macrophages. After intravenous injection, the concentrations of AZT were up to 18 times higher in organs belonging to the reticuloendothelial system (RES) when the drug was bound to nanoparticles than after injection of an aqueous AZT solution, Likewise, after oral administration the nanoparticle formulation delivered AZT more efficiently to the RES than the aqueous solution, In addition, the blood concentration was significantly higher after oral administration of nanoparticles. These results demonstrate that nanoparticles are a promising drug-targeting system for AZT to the RES organs. The increase in drug availability at the sites containing abundant macrophages may allow a reduction in dosage to avoid systemic toxicity.

  • Date created
    1996
  • Subjects / Keywords
  • Type of Item
    Article (Published)
  • DOI
    https://doi.org/10.7939/R39P2W725
  • License
    This is a copy of an article published in AIDS Research and Human Retroviruses © 1996 copyright Mary Ann Liebert, Inc.; AIDS Research and Human Retroviruses is available online at: http://online.liebertpub.com. This version of this article is open access and can be downloaded and shared. The original author(s) and source must be cited.
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  • Citation for previous publication
    • RAIMAR LÖBENBERG, JÖRG KREUTER. (1996). Macrophage Targeting of Azidothymidine: A Promising Strategy for AIDS Therapy. AIDS research and human retroviruses, 12(18), 1709-1715. DOI: 10.1089/aid.1996.12.1709.