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Skip to Search Results- 3Field, Catherine J.
- 2Ma, Liya
- 2Proctor, Spencer D.
- 1Adam, Ibrahim S. Y.
- 1Allan, Stuart M.
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- 21Graduate and Postdoctoral Studies (GPS), Faculty of
- 21Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 5Agricultural, Food and Nutritional Science, Department of
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Innate Immunity and the Retinal Pigment Epithelium in Gene Therapy for Inherited Retinal Disorders
DownloadFall 2021
Background: The photoreceptors are post-mitotic (no longer dividing), so the eye has evolved several unique immunological mechanisms to protect the photoreceptors and prevent vision loss. Inherited retinal disorders occur when mutations disrupt normal retinal function and photoreceptors die....
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Broccoli sprout supplementation during placental insufficiency confers structural and functional neuroprotection to the fetal rat
DownloadSpring 2010
Background: Perinatal ischemic brain injury leads to developmental disability (DD), which accounts for 30% of disabilities in children. Antepartum risk, or risk occurring prior to birth occurs in more than 90% of cases. This study investigated whether maternal ingestion of a natural health...
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Hippocampal neuroplasticity and neurogenesis in major depressive disorder: a high field MRI study
DownloadFall 2012
The hippocampus is a brain structure responsible for memory, learning, and the stress response; it is also used as a model for major depressive disorder (MDD) in preclinical studies. Preclinical models have shown that the hippocampal subfields are differentially affected by chronic stress....
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Analysis of goldfish innate immunity following exposure to oil sands process affected water
DownloadFall 2013
The acute and sub chronic effects of oil sands process affected water (OSPW) and its toxic component, naphthenic acids (NAs) were examined. I exposed goldfish for one (acute), or 12 (sub chronic) weeks and examined immune gene expression, macrophage function, the ability of exposed fish to...
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Fall 2016
Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) noninvasive method, capable of measuring perfusion, i.e. blood flow, with blood as an intrinsic contrast. ASL measurements of cerebral perfusion are usually acquired at very low spatial resolution (> 60mm3 voxels), for several...
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A microsatellite polymorphism in the gamma interferon gene is associated with resistance to gastrointestinal nematodes in a naturally-parasitized population of Soay sheep
Download2001
Pemberton, J. M., Coltman, D. W., Pilkington, J. G., Wilson, K., Stear, M. J.
Abstract: Free-living Soay sheep (Ovis aries) on the island of Hirta, St Kilda, Scotland, are naturally parasitized bq gastrointestinal nematodes, predominantly Teladorsagia circumcincta. In this paper we show that reduced faecal egg counts (FEC) are associated with an allele at a microsatellite...
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2018-10-16
SSHRC NFRF-E awarded 2019: With the requested funding, I will apply my expertise in T cells and metabolism to identify new potential metabolic drugs that can enhance immune function. We hypothesize that a Insulin-Resistance (IR)-related immune and metabolic defect contributes to increased risk of...