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Assessments of novel transgenic germplasm and treatment with the phytohormone cytokinin for reducing feeding damage by flea beetles, Phyllotreta spp. (Coleoptera: Chrysomelidae) in canola
DownloadFall 2011
Flea beetles Phyllotreta cruciferae (Goeze) and Phyllotreta striolata (Fabricius) (Coleoptera: Chrysomelidae) pose significant threats to early canola seedling establishment. The resistance potential of transgenic Brassica napus expressing cDNA encoding pea PR10.1 and 10.4 (ABR17) in Westar and...
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Genetic Engineering, Efficacy and Environmental Biosafety of Transgenic Pea (Pisum sativum L.)
DownloadSpring 2018
Canada is the worldâs largest producer and exporter of field peas (Pisum sativum L.). Plant productivity can be greatly reduced by biotic and abiotic stresses, including fungal diseases and drought. Biotechnological tools are available for enhancing tolerance against these stresses. We...
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Looking beyond the standard genome-wide association study: Biologically-motivated methodological approaches to discover novel genetic variants associated with complex human traits and disease
DownloadFall 2018
The standard approach for testing associations between common single nucleotide genetic variants (referred to as single nucleotide polymorphisms or SNPs) and disease entails testing disease associations for each SNP in the genome individually. This “hypothesis-free” approach has identified...
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Spring 2013
If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...
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Fall 2015
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
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Spring 2010
Development of the vertebrate central nervous system is a complex process that relies on the accurate spatiotemporal distribution of signaling centers during embryogenesis. These signals provide cells with positional information, which is integrated via transcription factors and gene regulatory...
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Fall 2018
Early mammalian development cannot progress without targeted temporal and spatial expression of genes. Changing the accessibility of DNA to transcriptional machinery is one critical way gene expression is controlled. This process, known as chromatin remodeling, is vital for formation of the...
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Transcriptional regulation of von Willebrand Factor gene in response to hypoxia and in cancer cells
DownloadFall 2016
Von Willebrand Factor (VWF) is a pro-coagulant, glycosylated protein that is exclusively expressed in endothelial cells and megakaryocytes. An acute phase protein, VWF is upregulated or released from activated or injured endothelial cells. In addition, it is a carrier for factor VIII that...