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Skip to Search Results- 1Aguirre Monroy, Angelica M
- 1Alam, Kazi, MM
- 1Baleja, James D.
- 1Booker, Brandon K.
- 1Chavali Venkata Subramanya, Ravi Shankar
- 1Chehel Amirani, Morteza
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Using Biomolecular Recognition to Selectively Self-Assemble Microscale Components onto Patterned Substrates
DownloadSpring 2015
Modern nanofabrication technology in the 21st century has continued year after year to push the boundaries of what is possible at the nanoscale. With the advent of molecular electronics, single electron devices, nanoelectromechanical systems (NEMS), and other nanotechnologies, the near future...
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Developing and Assessing an Environmental DNA Protocol for Detecting Amphibian Species in Lentic Systems in Alberta, Canada
DownloadSpring 2016
Global declines of amphibian populations have resulted in increased interest in determining and monitoring the geographic ranges for both endangered and invasive amphibian species. Monitoring programs rely on detection techniques to amass data, techniques that must be dependable in order to...
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Fall 2013
The aim of this work is to develop an effective non-viral carrier and to identify suitable gene targets that would induce apoptosis specifically in lymphoma cells upon down-regulation with short interfering RNA (siRNA). Lymphoma is common in children and young adults, and although survival rate...
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Investigations of interactions between membrane and PEI/siRNA nanoparticles and their implication for non-viral gene delivery
DownloadSpring 2021
Cell entry of polynucleotide-based therapeutic agents can be promoted by nanoparticle (NP) mediated delivery. This dissertation investigates membrane penetration of polynucleotide NPs, using mainly computational approaches, accompanied by some experiments. Major emphasis was placed on...
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A Coarse-Grained Simulation Framework to Study Polyethylenimine-DNA Nanoparticles in Gene Delivery
DownloadSpring 2022
Cellular DNAs contain genetic information vital for the functioning of the cells. Corruption of this information, or genetic disorders, can lead to various diseases. A potential treatment is to deliver exogenous DNAs with the correct genetic information to malignant cells to achieve a...
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Spring 2013
Chavali Venkata Subramanya, Ravi Shankar
The In-gel polymerase chain reaction (PCR) technology developed by our group at the University of Alberta makes use of PCR reagents entrapped within nano-liter polyacrylamide gels. To adapt this technology for use at the point of care, methods were developed to preserve gel-based PCR reagents by...
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Fall 2014
Developing a simple, general, and isothermal self-replicating system is one of the key requirements for a simplified detection platform for nucleic acid sequences specific to a disease causing microrganism. One of the challenges in achieving nucleic-acid templated isothermal amplification is that...
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Spring 2015
Protein silencing by small interfering RNA (siRNA) is a promising treatment strategy for cancer as over-expression of proteins is largely responsible for cancer cells’ infinite proliferation, evasion of cell death and multi-drug resistance. However, siRNAs require a carrier as their biological...
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Spring 2016
Hybrids formed by biological entities and human-made nano-structures have been intensively studied in recent years due to their very interesting properties and applications. DNA-carbon nanotube (CNT) hybrid is one such material and the motivation of this PhD study. The interaction of DNA building...