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Skip to Search Results- 25Microbiome
- 23Breast Cancer
- 17Chemotherapy
- 8Gastrointestinal Tract
- 7Clostridium
- 6Clostridium difficile
- 5Gänzle, Michael G.
- 3Finlay, B. Brett
- 3Willing, Benjamin P.
- 2Antunes, L. Caetano M.
- 2Armstrong, Glen D.
- 2Dieleman, Levinus
- 48Graduate and Postdoctoral Studies (GPS), Faculty of
- 48Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 12Agricultural, Food and Nutritional Science, Department of
- 12Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Chemistry, Department of
- 2Chemistry, Department of/Journal Articles (Chemistry)
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Campylobacter jejuni colonization is associated with a dysbiosis in the cecal microbiota of mice in the absence of prominent inflammation
Download2013
Selinger, L. Brent, Inglis, G. Douglas, Uwiera, Richard R. E., Lone, Abdul, Xu, Yong
Background Campylobacter jejuni causes enterocolitis in humans, but does not incite disease in asymptomatic carrier animals. To survive in the intestine, C. jejuni must successfully compete with the microbiota and overcome the host immune defense. Campylobacter jejuni colonization success varies...
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Na+/H+ exchange in the tumour microenvironment: Does NHE1 drive breast cancer carcinogenesis?
Download2015-01-01
Amith, Schammim Ray, Fong, Sunny, Baksh, Shairaz, Fliegel, Larry
Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal expression of their ion transporters and related...
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Diet and environment shape fecal bacterial microbiota composition and enteric pathogen load of grizzly bears
Download2011-01-01
Northrup, Joseph M., Cristescu, Bogdan, Schwab, Clarissa, Stenhouse, Gordon B., Gänzle, Michael G.
Background Diet and environment impact the composition of mammalian intestinal microbiota; dietary or health disturbances trigger alterations in intestinal microbiota composition and render the host susceptible to enteric pathogens. To date no long term monitoring data exist on the fecal...
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Development of A Gadolinium-Based Nanotheranostics Platform for Irradiation Activatable MRI-Radiosensitization and Doxorubicin Release in Cancer Therapy
DownloadSpring 2022
The ultimate goal of this thesis research was to design, fabricate, and characterize an integrated nanotheranostics platform for activatable doxorubicin delivery and simultaneous MRI- radiosensitization for synergistic cancer therapy, targeting breast cancer treatment. As shown in the diagram,...
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Spring 2022
BackgroundEvidence is emerging that the gut microbiome is an important contributor to the weight and metabolic effects of bariatric surgery. However, the microbial and intestinal physiological changes that occur with bariatric surgery are poorly understood. Developing this understanding...
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Fall 2021
Spinal cord injury (SCI) not only leads to motor and sensory dysfunction, but just as debilitating are secondary consequences of SCI such as bowel disorders, neuroinflammation, immune suppression, pain and psychiatric disorders. In this thesis, I explore multiple aspects of recovery after SCI in...
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Fall 2020
Introduction By 2030, 1/100 Canadians are predicted to be diagnosed with inflammatory bowel diseases (IBD); approximately 25% of cases are diagnosed in children. IBD include Crohn disease (CD) and ulcerative colitis (UC), and manifest with chronic gastrointestinal inflammation. Pathogenesis...
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Fall 2011
Breast cancer is the second leading cause of cancer death in Canadian women. In these patients, mortality is due to metastasis of cancer cells from the breast to distant organs, resulting in impairment of function. To metastasize, cells must move through the stroma of the breast, enter the...
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Non digestible carbohydrates in the diet determine toxicity of irinotecan (CPT-11)/5-fluorouracil in rats independently of β-glucuronidase activity in intestinal lumen
DownloadFall 2012
Aim of this study was to assess effects of non-digestible carbohydrates on the pathobiology of mucosal injury after chemotherapy. Rats bearing colon tumor (n=6/diet) were fed diets including 8% (w/w) as either cellulose, inulin, fructo-oligosaccharide (OligoF), 50:50 (w/w) inulin and oligoF...
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Cognitive Dysfunction in non-Hodgkin's Lymphoma Patients Treated with Front-Line Chemotherapy
DownloadSpring 2015
Despite the research to date, the characteristics and impact of cognitive dysfunction (CD) in cancer patients following chemotherapy is still not well understood. It is estimated approximately 20% of patients will manifest measurable cognitive deficits on neuropsychological testing...