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Non digestible carbohydrates in the diet determine toxicity of irinotecan (CPT-11)/5-fluorouracil in rats independently of β-glucuronidase activity in intestinal lumen

  • Author / Creator
    Farhangfar, Arazm
  • Aim of this study was to assess effects of non-digestible carbohydrates on the pathobiology of mucosal injury after chemotherapy. Rats bearing colon tumor (n=6/diet) were fed diets including 8% (w/w) as either cellulose, inulin, fructo-oligosaccharide (OligoF), 50:50 (w/w) inulin and oligoF (Synergy®), isomalto-oligosaccharide (IMO), type IV resistant starch (RS4) or cornstarch. Animals were treated with 2 cycles of CPT-11/5-fluorouracil. Animals fed RS4 or Synergy® were least ill with the least weight loss and anorexia, highest levels of gut associated lymphoid tissue (GALT) CD3+ and CD3CD8+ cells, least acute phase responses (haptoglobin, α-1-acid glycoprotein), least GALT OX6+ cells, CD152+ and CD71+ expression on CD8+ cells. Animals fed IMO or cornstarch were the most ill by these same criteria (p<0.05); animals fed inulin, cellulose and OligoF showed intermediate sickness. Dietary NDCHO determine chemotherapy toxicity in a controlled model of colon cancer treatment, this may be due to change in immune function.

  • Subjects / Keywords
  • Graduation date
    2012-11
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3W13D
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Agricultural, Food, and Nutritional Science
  • Specialization
    • Nutrition and Metabolism
  • Supervisor / co-supervisor and their department(s)
    • Baracos, Vickie (Oncology, Agricultural, Food, and Nutritional Science)
  • Examining committee members and their departments
    • Field, Catherine (Agricultural, Food, and Nutritional Science)
    • Mazurak, Vera (Agricultural, Food, and Nutritional Science)
    • Sawyer, Michael (Oncology)
    • Baracos, Vickie (Oncology, Agricultural, Food, and Nutritional Science)