Search
Skip to Search Results- 1Baluch, Aliyah
- 1Bergeron, Amber
- 1Brachmann, Cole Garrett
- 1Conway, Jennifer
- 1Jin, Chaochao
- 1Kong, Jude D
- 3Department of Medicine
- 2Department of Mathematical and Statistical Sciences
- 2Faculty of Nursing
- 2School of Public Health
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Biological Sciences
- 2Wang, Hao (Mathematical and Statistical Sciences)
- 1Anderson, Colin (Medical Microbiology and Immunology)
- 1Clandinin, M. Tom (Agricultural, Food, and Nutritional Sciences
- 1Colleen Norris (Faculty of Nursing)
- 1Deepali Kumar, MD (Transplant Infectious Diseases)
- 1Dr. Deepali Kumar (Medicine)
-
Fall 2017
This thesis focuses on formulating and analyzing non linear models for microbial dynamics vis-a-vis human and environmental health. Firstly, we develop and investigate a stoichiometric organic matter decomposition model in a chemostat culture that incorporates the dynamics of grazers. This...
-
Spring 2010
These two studies investigate the immune responses of lung and kidney transplant recipients to the influenza vaccine. The study involving kidney transplant recipients developed a novel flow cytometry assay to measure cell-mediated immunity in response to influenza vaccination. The activation of...
-
Proximal Impact of Transplant Tolerance-Promoting Antibody Therapies on Antigen-Specific T Cell Reactivity
DownloadFall 2013
The development of a transient, tolerance-promoting therapy is a critical goal in transplantation. Antibody-perturbation of T cell activation signals is considered a promising candidate. However, the mechanisms of such therapies remain vague. The lack of cohesive and systematic knowledge in the...
-
Spring 2021
Mechanical circulatory support has become a therapeutic option for children with advanced heart failure. This type of support is often used to bridge patients to heart transplantation with approximately a third of all patients listed for transplant requiring some form of mechanical support. While...
-
Spring 2015
Background: Heart transplant is life-saving for children with end-stage congenital heart disease or acquired heart failure. Critical illness following transplantation can include acute kidney injury (AKI). There is little data on the epidemiology of, risk factors for, or impact on outcomes of...
-
Fall 2016
Background: NK cells are a key cellular component of antibody-mediated rejection (ABMR), but their role in ABMR has not been identified. We postulated that NK cells are stimulated through their CD16a antibody receptors by donor-specific anti-HLA antibodies in ABMR. There is currently no direct...
-
Mathematical Models and Inverse Algorithms for Childhood Infectious Diseases with Vaccination - Case Studies in Measles
DownloadFall 2014
Children are at a high risk of infection since they have not yet developed mature immunity. Childhood infectious diseases, such as measles, chicken pox and mumps, remain epidemic and endemic around the world. Yet, their dynamics are still not fully understood. SIR-type models have been proposed...
-
Diabetes and Influenza-Attributable Illness: The Rationale for Targeted Influenza Vaccinations in Adults with Diabetes
DownloadFall 2012
While guidelines for seasonal influenza vaccinations single out working age (< 65) adults with diabetes, vaccination rates in this group remain below national targets. Historically, there has been limited evidence to support these guidelines. This dissertation comprises four studies investigating...
-
Fall 2017
In recent years, narratives about various embellished and imaginary risks of vaccination have come under criticism because of their implications for the widespread acceptance of vaccines. Criticisms of these narratives often accompany assumptions that all mainstream health professionals accept,...
-
Investigation of fatty acid and cholesterol synthesis using stable isotopes in type 1 diabetes, liver failure, islet and liver transplant, and effect of dietary intervention
DownloadSpring 2011
Elevated plasma lipids are risk factors for cardiovascular disease (CVD). In certain conditions plasma lipids are normal yet individuals experience increased morbidity. Type 1 diabetes (T1D) is associated with elevated CVD despite normal lipids, while in liver failure low plasma lipids may...