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Skip to Search Results- 1Baluch, Aliyah
- 1Bergeron, Amber
- 1Brachmann, Cole Garrett
- 1Conway, Jennifer
- 1Jin, Chaochao
- 1Kong, Jude D
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Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
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Fall 2017
This thesis focuses on formulating and analyzing non linear models for microbial dynamics vis-a-vis human and environmental health. Firstly, we develop and investigate a stoichiometric organic matter decomposition model in a chemostat culture that incorporates the dynamics of grazers. This...
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Spring 2010
These two studies investigate the immune responses of lung and kidney transplant recipients to the influenza vaccine. The study involving kidney transplant recipients developed a novel flow cytometry assay to measure cell-mediated immunity in response to influenza vaccination. The activation of...
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Proximal Impact of Transplant Tolerance-Promoting Antibody Therapies on Antigen-Specific T Cell Reactivity
DownloadFall 2013
The development of a transient, tolerance-promoting therapy is a critical goal in transplantation. Antibody-perturbation of T cell activation signals is considered a promising candidate. However, the mechanisms of such therapies remain vague. The lack of cohesive and systematic knowledge in the...
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Spring 2021
Mechanical circulatory support has become a therapeutic option for children with advanced heart failure. This type of support is often used to bridge patients to heart transplantation with approximately a third of all patients listed for transplant requiring some form of mechanical support. While...
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Spring 2015
Background: Heart transplant is life-saving for children with end-stage congenital heart disease or acquired heart failure. Critical illness following transplantation can include acute kidney injury (AKI). There is little data on the epidemiology of, risk factors for, or impact on outcomes of...
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Fall 2016
Background: NK cells are a key cellular component of antibody-mediated rejection (ABMR), but their role in ABMR has not been identified. We postulated that NK cells are stimulated through their CD16a antibody receptors by donor-specific anti-HLA antibodies in ABMR. There is currently no direct...
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Characterizing the effects of differentially adapted influenza PB2 proteins on duck MAVS-mediated interferon beta signaling
DownloadFall 2015
The influenza A viral RNA polymerase is responsible for viral replication and greatly affects influenza A virus (IAV) virulence and host range. The PB2 influenza polymerase subunit is the primary polymerase determinant of influenza host range and virulence. It was previously shown that PB2...
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Mathematical Models and Inverse Algorithms for Childhood Infectious Diseases with Vaccination - Case Studies in Measles
DownloadFall 2014
Children are at a high risk of infection since they have not yet developed mature immunity. Childhood infectious diseases, such as measles, chicken pox and mumps, remain epidemic and endemic around the world. Yet, their dynamics are still not fully understood. SIR-type models have been proposed...
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Fall 2020
Infectious respiratory diseases, caused by viruses and bacteria that attack the respiratory system, constitute a serious threat in public health around the world. Pathogens can be transmitted in the air though large droplets or aerosols. As aerosols can linger in the environment for a prolonged...