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2010
Clawson,M. L., Wang, Z., Stothard, P., McKay, S., Laegreid, W. W., Williams J. L., Murdoch, B. M., Settles, M., Moore, S. S., Prasad, A.
Background Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Polymorphisms that alter the prion protein of sheep or humans have been associated with variations in...
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An Assessment of Population Structure in Eight Breeds of Cattle Using a Whole Genome SNP Panel
Download2008
Schnabel, R. D., Wang, Z., Taylor, J. F., Gill, C. A., Van Tassell, C. P., Gao, C., Aerts, J., Williams, J. L., Neto, E. D., Murdoch, B. M., Matukumalli, L. K., Coppieters, W., McKay, S. D., Mannenl, H., Crews, D., Moore, S. S.
Background Analyses of population structure and breed diversity have provided insight into the origin and evolution of cattle. Previously, these studies have used a low density of microsatellite markers, however, with the large number of single nucleotide polymorphism markers that are now...
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Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels
Download2002
Fitzsimmons, C. J., Thue, T. D., Buchanan, F. C., Winkelman-Sim, D. C., Schmutz, S. M., Van Kessel, A. G.
Previously, we have shown that alleles of the BM1500 microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid...
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Expansion of ruminant-specific microRNAs shapes target gene expression divergence between ruminant and non-ruminant species
Download2013
Kommadath, A., Bao, H., Meng, Y., Plastow, G. S., Stothard, P., Sun, X., Arantes, A. S., Guan, L. L.
Background Understanding how species-specific microRNAs (miRNAs) contribute to species-specific phenotypes is a central topic in biology. This study aimed to elucidate the role of ruminant-specific miRNAs in shaping mRNA expression divergence between ruminant and non-ruminant species. ...
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2008
Kolbehdari, D., Stothard, P., Schnabel, R., Wang, Z., Marques, E., Taylor, J. F., Moore, S. S.
Background Linkage disequilibrium (LD) maps can provide a wealth of information on specific marker-phenotype relationships, especially in areas of the genome where positional candidate genes with similar functions are located. A recently published high resolution radiation hybrid map of bovine...
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High resolution radiation hybrid maps of bovine chromosome 19 and 29 and comparison with the bovine genome sequence assembly
Download2007
Murdoch, B., Wang, Z., Stothard, P., Womack, J. E., Mckay, S. D., Moore, S. S., Schiex, T., Prasad, A.
Background High resolution radiation hybrid (RH) maps can facilitate genome sequence assembly by correctly ordering genes and genetic markers along chromosomes. The objective of the present study was to generate high resolution RH maps of bovine chromosomes 19 (BTA19) and 29 (BTA29), and...
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1988
Plastow, G. S., Mileham, A. J., Siggens, K. W.
A 3.8 kb male specific fragment was observed following agarose gel etectrophoresis of porcine DNA digested with Sph I. DNA was recovered from this region of a gel using DE-81 paper and ligated to Sph I digested pUC18. Plasmids carrying male specific sequences were identified by their differential...
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2007
Schnabel, R. D., Wang, Z., Mannenl, H., Gill, C. A., Van Tassell, C. P., Gao, C., Aerts, J., Williams, J. L., Neto, E. D., Moore, S. S., Matukumalli, L. K., Coppieters, W., McKay, S. D., Taylor, J. F., Crews, D., Murdoch, B. M.
Background Bovine whole genome linkage disequilibrium maps were constructed for eight breeds of cattle. These data provide fundamental information concerning bovine genome organization which will allow the design of studies to associate genetic variation with economically important traits and...