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Skip to Search Results- 14Hypertension
- 8Cardiac hypertrophy
- 3Arachidonic acid
- 3Blood Pressure
- 3Cytochrome P450
- 3Inflammation
- 3Majumder, Kaustav
- 3Wu, Jianping
- 2Chakrabarti, Subhadeep
- 2Davidge, Sandra T.
- 2Jahandideh, Forough
- 2Kaufman, Susan
- 13Graduate and Postdoctoral Studies (GPS), Faculty of
- 13Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 3Agricultural, Food and Nutritional Science, Department of
- 3Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Pharmacy and Pharmaceutical Sciences, Faculty of
- 1Pharmacy and Pharmaceutical Sciences, Faculty of/Research Day (University of Alberta Faculty of Pharmacy and Pharmaceutical Sciences)
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Molecular targets of antihypertensive peptides: Understanding the mechanisms of action based on the pathophysiology of hypertension
Download2015
Majumder, Kaustav, Wu, Jianping
There is growing interest in using functional foods or nutraceuticals for the prevention and treatment of hypertension or high blood pressure. Although numerous preventive and therapeutic pharmacological interventions are available on the market, unfortunately, many patients still suffer from...
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Pharmacist Management of Hypertension: An Examination of Clinical and Economic Outcomes and Remuneration for Expanded Services
DownloadSpring 2014
Background: One-third of Canadian adults with hypertension remain uncontrolled. As drug therapy experts, pharmacists can play a role in addressing this challenge, particularly when utilizing prescribing authorization in Alberta. However, the clinical effectiveness of pharmacist management of...
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Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk
Download2014-01-01
Huyard, Fanny, Yzydorczyk, Catherine, Castro, Michele M., Cloutier, Anik, Bertagnolli, Mariane, Sartelet, Hervé, Schulz, Richard, Nuyt, Anne Monique
Neonatal high-oxygen exposure leads to elevated blood pressure, microvascular rarefaction, vascular dysfunction and arterial (aorta) rigidity in adult rats. Whether structural changes are present in the matrix of aorta wall is unknown. Considering that elastin synthesis peaks in late fetal life...
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Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity
DownloadSpring 2013
Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...
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Role of Cytochrome P450 1B1 in Inflammation-induced Cardiac Hypertrophy
2023-05-17
ElKhatib, Mohammed, El-Kadi, Ayman
A great deal of research has demonstrated the involvement of cytochrome P450 (CYPs) enzymes and its metabolism of arachidonic acid (AA) in the modulation of cardiac hypertrophy (CH) pathogenesis. Multiple studies demonstrated that inflammation is a major contributor to CH and is known to...
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Spring 2021
As one of the most accessible primary health care providers, pharmacists are in an excellent position to provide primary health care services. Although slow, the current transition from a dispensing-centered (transaction-based) pharmacy approach to a patient-centered (patient care based) approach...
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Spring 2016
Introduction: Lumbar Spinal Stenosis (LSS) is a prevalent musculoskeletal condition affecting 8-11% of the United States general population. LSS is the most common reason requiring lumbar spine surgery in adults older than 65 years, with an adjusted rate of 135.5 low back surgeries per 100,000...
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THE ROLE OF CYTOCHROME P450 AND THEIR ASSOCIATED ARACHIDONIC ACID METABOLITES IN THE INITIATION AND PROGRESSION OF CARDIAC HYPERTROPHY
DownloadSpring 2016
Heart failure (HF) is the leading cause of mortality and disability in adults worldwide. Cardiac hypertrophy is an independent risk factor and one of the major hallmarks of HF. Research in cardiac hypertrophy is considered as a research into the early events in the development of HF. The...
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Fall 2017
The adipocyte-derived lipokine, C16:1n7-palmitoleate, regulates a variety of functions such as systemic glucose and fatty acid metabolism. Under normal physiological conditions, palmitoleate levels are regulated by de novo lipogenesis. During pathological conditions where there are enhanced rates...
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The role of cytochrome P450 derived arachidonic acid metabolites against Angiotensin II-induced cardiac hypertrophy in Sprague Dawley rats and the RL-14 cell line
DownloadFall 2015
Several cytochrome P450 (CYP) enzymes and their arachidonic acid (AA) metabolites play essential roles in the maintenance of cardiovascular health, and their alteration gives rise to a number of cardiovascular diseases, including cardiac hypertrophy and heart failure. Recent data demonstrated...