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Skip to Search Results- 1Abdulsalam Alharbi
- 1Akhnokh, Maria Kodsy
- 1Aktary, Zackie M
- 1Al Lawati, Hanan M
- 1Alolayan, Waad Riyad
- 1Alshamsan, Aws
- 14Faculty of Pharmacy and Pharmaceutical Sciences
- 13Department of Agricultural, Food, and Nutritional Science
- 9Department of Medicine
- 9Department of Oncology
- 5Department of Biochemistry
- 4Centre for Neuroscience
- 3Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2Foley, Edan (Medical Microbiology and Immunology)
- 2Jamali, Fakhreddin (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2Kerr, Bradley (Anesthesiology and Pain Medicine)
- 2Lemire, Bernard (Biochemistry)
- 2McNeely, Margaret (Rehabilitation Medicine)
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Fall 2015
There is a concern that brain tumours are underreported in the Alberta Cancer Registry (ACR), yet no studies have been performed to investigate this issue. This study addresses the concern of underreporting of brain tumours in the ACR by assessing case ascertainment of primary brain tumours cases...
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Comparison of tooth loss between intensity modulated and non-intensity modulated radiotherapy in head and neck cancer patients
DownloadFall 2011
Advanced radiotherapy (RT) systems (intensity modulated radiotherapy, IMRT) is widely used to treat head and neck cancer. A combination of radiation and chemotherapy potentially increases toxicity as well as dental complications. Tooth loss was retrospectively assessed using oral cavity,...
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Fall 2009
The analysis of wide-angle cellular light scattering patterns is a challenging problem. Small changes to the organization, orientation, shape, and optical properties of scatterers and scattering populations can significantly alter their complex two-dimensional scattering signatures. Because of...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Deciphering the mechanism(s) which limit reovirus spread in resistant lung and HNSCC cancer cells
DownloadFall 2016
Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Development of Novel Polymeric Micellar DACHPt for Enhanced Platinum Based Chemotherapy in Colorectal Cancer
DownloadSpring 2019
One of the major limitations of chemotherapy in cancer treatment is the side effects of anti-cancer drugs. This happens due to non-selective distribution of most standard chemotherapies, and their action on cancer and all normal dividing cells. The objective of this project is to develop a novel...
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Fall 2013
The aim of this work is to develop an effective non-viral carrier and to identify suitable gene targets that would induce apoptosis specifically in lymphoma cells upon down-regulation with short interfering RNA (siRNA). Lymphoma is common in children and young adults, and although survival rate...
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Development of block copolymer based nanocarriers for the solubilization and delivery of valspodar
DownloadFall 2011
One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR), where cancer cells become resistant to different types of anticancer drugs. Over-expression of membrane efflux pumps like P-glycoprotein (P-gp), which recognizes different chemotherapeutic agents and...