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- 38Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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- 3Kinesiology, Sport, and Recreation, Faculty of
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MOLECULAR AND PHENOTYPIC CHARACTERIZATION OF DISTINCT BREAST CANCER CELL SUBPOPULATIONS PURIFIED USING A SOX2 REGULATORY REGION 2 TRANSCRIPTION ACTIVITY REPORTER
DownloadFall 2015
Sex-determining Region Y-box 2 (Sox2) is a transcription factor integral to the maintenance of pluripotency in embryonic stem cells. In recent years, Sox2 expression has been detected and implicated in the pathogenesis of breast and other cancers. Clinically, Sox2 expression has been associated...
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Fall 2012
Despite originally being described as a secreted protease, matrix metalloproteinase‐2 (MMP‐2) was recently revealed to have targets within cardiomyocytes. The biological mechanism(s) that describes the intracellular localization of MMP‐2 is unknown and is thus the subject of this thesis....
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2016-12-09
Winter, Philip, Wang, Xumin, Mackey, John R. , Lee, John C. , Wong, Gane Ka-Shu, Ghosh, Sunita, Patterson, Jordan, Zhang, Hangxiao, Wang, Weiwei, Tuszynski, Jack A. , Katsetos, Christos D., Graham, Kathryn, Luduena, Richard F.
Tubulin is the target for very widely used anti-tumor drugs, including Vinca alkaloids, taxanes, and epothilones, which are an important component of chemotherapy in breast cancer and other malignancies. Paclitaxel and other tubulin-targeting drugs bind to the β subunit of tubulin, which is a...
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Fall 2010
In Canada, obesity and associated chronic diseases disproportionately affect First Nations children. The objectives of this research were to assess obesity, physical activity, and perceptions of lifestyle behaviors in Cree First Nations children (5-12 years) in one Alberta reserve community....
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
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2005
It is important to seek an understanding of teenagers’ perceptions regarding teenage pregnancy. The purpose of this study was to explore and describe the perceptions of teenagers in Bushbuckridge district in the Limpopo Province, South Africa, towards teenage pregnancy. An explorative qualitative...
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2012
I have conducted a single-case heuristic study of my engagement with breast cancer and how the collective pressure to think positively affected me. I explore the shadow, or the unrecognized significance, that positive thinking placed upon my healing process. I argue that the tacit implication...
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2012
Farhadifar, F., Taymoori, P., Berry, T.
Objective: Despite evidence that screening for breast cancer is effective, adherence with screening recommendations in Iranian women is low. The purposes of this study were to (1) identify the associations between individual characteristics, related health beliefs, and stages of mammography...
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PRRD Quantitative content analysis
2015-02-05
Quantitative content analysis of media collected for CIHR funded study \"Pink Ribbons and Red Dresses: the relationship between disease awareness campaigns, health-related cognitions and perceptions of preventive behaviours.\"