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Skip to Search Results- 9Arachidonic acid
- 5Glioma
- 3Cardiac hypertrophy
- 3Docosahexaenoic acid
- 2Brain fatty acid-binding protein
- 2Cytochrome P450
- 1Aghazadeh Habashi, Ali
- 1Al Lawati, Hanan M
- 1Alsaad,Abdulaziz M
- 1Beaulieu, Michael J.
- 1Brun, Miranda
- 1El-Sherbeni, Ahmed Abd El-Hakeem
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis
DownloadSpring 2015
Crystalline glucosamine (GlcN) sulfate salt formulation is approved as a prescription drug with anti-inflammatory effects for the management of osteoarthritis (OA) in the European Union, while it is considered as a nutraceutical in North America. The effectiveness of GlcN for ameliorating the...
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Fall 2022
From the mechanical processes that produce the convolutions in the human brain needed for complex thought, to the precise and controlled movements derived by intuitive calculations of body position in figure skating, mechanics plays a role in everything we do. In this thesis, we apply and examine...
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Fall 2021
Glioblastoma (GBM) is the most common primary brain malignancy and has a dismal prognosis. Despite advanced therapies, including surgery and concurrent radiotherapy with temozolomide (TMZ), GBM patients only have a 14.6-month median survival time. This dismal outcome can be attributed to the...
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Fall 2012
Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the migratory behaviour of...
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The role of cytochrome P450 derived arachidonic acid metabolites against Angiotensin II-induced cardiac hypertrophy in Sprague Dawley rats and the RL-14 cell line
DownloadFall 2015
Several cytochrome P450 (CYP) enzymes and their arachidonic acid (AA) metabolites play essential roles in the maintenance of cardiovascular health, and their alteration gives rise to a number of cardiovascular diseases, including cardiac hypertrophy and heart failure. Recent data demonstrated...
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Fall 2016
Gliomas, tumours arising from the glial cells of the nervous system, are some of the most difficult tumours to treat. In particular, glioblastoma are a particularly aggressive glioma subtype carrying a life expectancy of only 14 months. Typically, treatment combines surgery, radiation and...
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Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity
DownloadSpring 2013
Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...
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Fall 2010
Patients diagnosed with malignant glioma tumours have median survivals of 1.6 yrs and 5 months, respectively, highlighting the deadly nature of this disease. Despite aggressive multimodal treatment, patients with malignant glioma often present with secondary brain tumours at sites distal to the...
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Maternal Essential Fatty Acid Status During Pregnancy and Postpartum in the Alberta Pregnancy Outcomes and Nutrition (APrON) Study and Infant Outcomes
DownloadSpring 2017
Docosahexaenoic (DHA) and arachidonic (AA) acids are essential fatty acids found in breast milk and are important for the infant’s brain development and cognitive functions such as those that regulate sleep and crying. The overall goal of this research was to use a large maternal infant cohort,...