Mechanistic Insight Into the Role of FABP7 in Malignant Glioma

• Author / Creator

  Beaulieu, Michael J.

• Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the
  migratory behaviour of FABP7-positive MG cells is mediated by ligands of FABP7. We hypothesize that FABP7 plays a central role in stabilizing the aggressive behaviour of MG cells in a manner that is dependent on the COX-2 pathway.

  Here, we demonstrate that FABP7 alters the gene expression profile of MG cells, and the expression of potent inflammatory mediators. We provide evidence for a ligand-specific interaction between FABP7 and PPAR-β/δ, which could have consequences in mediating FABP7- dependent gene expression. We also demonstrate a role for FABP7 in modulating the AA and DHA content of nuclear phospholipid classes, and suggest that DHA maybe useful for treatment of MG.

• Subjects / Keywords

  • Docosahexaenoic acid
  • Nuclear phospholipids
  • Brain fatty acid-binding protein
  • Treatment of glioma with fatty acids
  • FABP7
  • Glioma
  • Arachidonic acid
  • COX-2

• Graduation date

  Fall 2012

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3RT33

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.