Search
Skip to Search Results- 1Farajizadeh, Arian
- 1Klaczek, Chantelle E
- 1Locke, Andrew J
- 1Lu, Lei
- 1MacDonald, Shannon E.
- 1Mehinrad, Parnian
- 3Department of Biological Sciences
- 3Department of Chemical and Materials Engineering
- 2Department of Chemistry
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Biochemistry
- 1Faculty of Nursing
- 3Goss, Greg (Biological Sciences)
- 1Chen, Lingyun (Agricultural, Food and Nutritional Science)
- 1Dr. Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Dr. Nils O. Petersen, Department of Chemistry
- 1Glover, Chris (Science and Technology, Athabasca University)
- 1Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
-
Spring 2011
The objective of this thesis is to design nanoparticle (NP)-based drug delivery systems suitable for treatment of bone diseases. Two types of nanocarriers, (1) polymer coated bovine serum albumin (BSA) NPs and (2) lipid based NPs (micelles and liposomes) were investigated. The BSA NPs were...
-
Cell-electronic Sensing of Cellular Responses and Toxicity Induced by Nanoparticles and Arsenic Species
DownloadFall 2013
We demonstrate the development of a real-time cell analysis (RTCA) platform for studying nanoparticle- and arsenic-induced cytotoxicity with potential applications to risk assessment, environmental toxicity monitoring, and drug development. RTCA is an impedance-based in vitro detection system...
-
Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
-
Exploring the Association between Parental Concern about Vaccine Safety and Incomplete Childhood Immunization: A Multivariate Model
DownloadSpring 2013
High levels of immunization coverage are required to maintain control of infectious diseases that previously caused significant illness and death in Canada. However, childhood immunizations have been so successful that many Canadians have never seen the impact of these diseases, with some parents...
-
Intestinal Uptake of Barley Protein Nanoparticles as Delivery Vehicles for Bioactive Compounds
DownloadFall 2013
The use of nanoparticles as nutrient delivery vehicles enables the enhancement of the oral bioavailability and health promoting benefits of bioactive compounds. Barley protein nanoparticles were developed in previous study for hydrophobic compound delivery. The objective of the present study was...
-
Modulation of the uptake and toxicity of PFOA by Polystyrene and Titanium dioxide nanoparticles in Pacific oysters (Magallana gigas) and Daphnia (Daphnia magna)
DownloadFall 2023
Nanomaterial toxicity is a major concern in today’s world. The benefits of nanoparticle use have led to the production of various kinds of nanomaterials including a high volume of nanoplastics, TiO2 nanoparticles, and CeO nanoparticles. Different nanomaterials are shown to be a suitable vector...
-
Nanodelivery of Novel Inhibitors of ERCC1/XPF for sensitizing colorectal cancer cell to platinum drugs
DownloadSpring 2023
This project's long-term goal is to increase the efficacy of genotoxic therapeutics through thesensitization of cells to DNA-damaging therapy ahead of the treatment. The focus of this projectwas on the enhancement of platinum-based chemotherapeutics in colorectal cancer usingcolorectal cancer...
-
Spring 2012
The present thesis describes preliminary studies required for evaluating silicon nanocrystals (Si-NCs) as photothermal (PT) therapy agents and drug delivery vehicles. Group 14 semiconductor NCs are of particular interest for these applications because of their tailorable optical response and...
-
Fall 2017
Inflammation is generally considered to be a protective response, however the effects of inflammation can also be harmful and even fatal. The study of regulating the inflammatory response in damaged tissue by using engineered biomaterials is not only essential for enhancing the biocompatibility...
-
Sustained Drug Release And Antibacterial Activity Of Ampicillin incorporated Poly (methyl methacrylate)-Nylon6 Core/Shell Nanofibers
DownloadFall 2012
A drug delivery system was designed based on the encapsulation of Ampicillin sodium salt in Poly (methyl methacrylate)(PMMA)-Nylon6 core/shell nanofibers and the release characteristics and antibacterial activity of the system were investigated. It was revealed that the system is capable of...