Sustained Drug Release And Antibacterial Activity Of Ampicillin incorporated Poly (methyl methacrylate)-Nylon6 Core/Shell Nanofibers

• Author / Creator

  Sohrabi, Amirreza

• A drug delivery system was designed based on the encapsulation of Ampicillin sodium salt in Poly (methyl methacrylate)(PMMA)-Nylon6 core/shell nanofibers and the release characteristics and antibacterial activity of the system were investigated. It was revealed that the system is capable of releasing the drug with a sustained manner through a three stages release in which the release in stage I followed the non-Fickian diffusion; however, Fickian diffusion was proven to be the release mechanism of stages II and III. The diffusion coefficient calculations indicated a significant decrease in the coefficient from stage II to stage III which is believed to be the consequent of fibers crystallization as a result of the long-term incubation in an aqueous solution. Finally, the antibacterial activity of the system was verified by means of optical density (OD) measurements against gram positive L.innocua.

• Subjects / Keywords

  • Core/shell fibers
  • Antibacteria activity
  • Drug release
  • Drug delivery
  • Electrospinning
  • Kinetics of drug release

• Graduation date

  Fall 2012

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3XH6P

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.