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Skip to Search Results- 2Binding-Site
- 1Coupling-Constants
- 1Cysteine-Scanning Mutagenesis
- 1Dependent Epitope
- 1Env Trimers
- 1Escape
- 1Briney, Bryan
- 1Burton, Dennis R.
- 1Cheng, Florence J.
- 1Cottrell, Christoph A.
- 1Fliegel, Larry
- 1Hsueh, Jessica
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Holes in the glycan shield of the native HIV envelope are a target of trimer-elicited neutralizing antibodies
Download2016
Hsueh, Jessica, Menis, Sergey, Sanders, Rogier W., Ozorowski, Gabriel, Pauthner, Matthias, Voss, James E., van Gils, Marit J., Torres, Jonathan L., McCoy, Laura E., Ward, Andrew B., Wilson, Ian A., Schief, William R., Macauley, Matthew S., Burton, Dennis R., Cottrell, Christoph A., Messmer, Terrence, Sok, Devin, Briney, Bryan, Kulp, Daniel W.
A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization. Here, potently neutralizing monoclonal antibodies (nAbs) from rabbits immunized with BG505 SOSIP.664 are shown to...
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Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the na+/H+ exchanger
Download2005-01-01
Slepkov, Emily R., Rainey, Jan K., Li, Xiuju J., Liu, Yonghsheng S., Cheng, Florence J., Lindhout, Darrin A., Sykes, Brian D., Fliegel, Larry
The Na+/H+ exchanger isoform 1 is a ubiquitously expressed integral membrane protein that regulates intracellular pH in mammals. We characterized the structural and functional aspects of the critical transmembrane (TM) segment IV. Each residue was mutated to cysteine in cysteine-less NHE1. TM IV...