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Skip to Search Results- 8Nitric Oxide
- 7Sex differences
- 6Vasoconstriction
- 4Sympatholysis
- 3Exercise
- 3Sympathetic nervous system
- 1Bartlett, Nathan T
- 1Brotto,Andrew R
- 1Collison, Breanne
- 1Cooper, Ian R
- 1Cox, Pendleton J M
- 1El-Sehemy, Ahmed Ali Ahmed Ali
- 5Physical Education and Recreation
- 2Centre for Neuroscience
- 2Department of Physiology
- 2Department of Psychology
- 2Faculty of Kinesiology, Sport, and Recreation
- 1Department of Biological Sciences
- 1Bell, Gordon (Physical Education and Recreation)
- 1Carlos A Velázquez (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Darren DeLorey, PhD Faculty of Physical Education and Recreation; Rehabilitation Medicine
- 1Davidge, Sandra (dept. of Physiology)
- 1DeLorey, Darren (Physical Education and Recreation)
- 1DeLorey, Darren Faculty of Kinesiology, Sport, and Recreation
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Notch regulates the growth-promoting nitric oxide cGMP-dependent pathway in epithelial ovarian cancer and ovarian surface epithelium cells
DownloadSpring 2014
El-Sehemy, Ahmed Ali Ahmed Ali
Ovarian cancer is the leading cause of mortality among gynecologic cancers. There are several subtypes of ovarian cancer, amongst which epithelial ovarian cancer (EOC) makes up to 90% of all ovarian cancers. The current treatment for EOC consists of debulking surgery followed by a...
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NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health Authorities
DownloadSpring 2012
The objective of this work was to synthesize and evaluate the biological properties of a new series of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol linker between the carboxylic acid present in classical NSAIDs and a NO-releasing group (PROLI/NO)...
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Fall 2016
Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer’s disease (AD) and preclinical cognitive and memory decline in older adults. We investigated whether memory resilience to genetic risk (i.e., Apolipoprotein E [APOE] ɛ4, Clusterin [CLU] CC, and a high additive...
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Skeletal Muscle Sympathetic Vasoconstrictor Control Following Short-Term Mild- and Heavy-Intensity Exercise Training
DownloadFall 2013
The purpose of this thesis was to investigate the effects of short-term endurance exercise training (ET) on sympathetic vasoconstriction in resting and contracting skeletal muscle. To achieve these aims, rats were exercise trained on a motorized treadmill and an anesthetised whole animal in situ...
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The effect of aerobic fitness on the cardiovascular and sympathetic nervous system response to physiological stress at rest and during dynamic exercise
DownloadFall 2012
A cardio-protective adaptation associated with aerobic fitness may be an attenuated sympathetic nervous system (SNS) and cardiovascular response to stress. The hypothesis that the cardiovascular and SNS responses to physiological stress at rest and during exercise would be a function of...
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The Effect of Inhaled Nitric Oxide on Maximal Oxygen Consumption in High-fit and Untrained Individuals
DownloadFall 2019
Previous work suggests that endurance-trained athletes have superior pulmonary vasculature function as compared to untrained individuals, which may contribute to their greater maximal oxygen uptake (V̇O2max). Inhaled nitric oxide (iNO) improves pulmonary vascular compliance at rest in healthy...
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Spring 2022
Background: Carbon monoxide alters cardiovascular function through its actions as a signaling molecule and by limiting oxygen delivery in the blood, favouring pro-dilatory and anti-constrictor effects within the vasculature. The impacts of mild carbon monoxide exposure on vascular responses to...
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Βeta-adrenergic receptors and opposition of evoked sympathetic vasoconstriction: Effects of sex and exercise training
DownloadFall 2016
Stimulation of the sympathetic nervous system evokes the release of neurotransmitters and produces vasoconstriction that is primarily mediated by the binding of norepinephrine (NE) to alpha-adrenergic receptors. However, NE may also bind to beta (β)-adrenergic receptors and produce vasodilation...