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Skeletal Muscle Sympathetic Vasoconstrictor Control Following Short-Term Mild- and Heavy-Intensity Exercise Training

  • Author / Creator
    Jendzjowsky, Nicholas G
  • The purpose of this thesis was to investigate the effects of short-term endurance exercise training (ET) on sympathetic vasoconstriction in resting and contracting skeletal muscle. To achieve these aims, rats were exercise trained on a motorized treadmill and an anesthetised whole animal in situ vascular preparation was used to investigate the effects of ET on sympathetic vascular control in resting and contracting skeletal muscle. Exercise training augmented resting sympathetic vasoconstrictor responsiveness in a training intensity-dependent manner. Concurrently, endothelium-dependent vasodilation was augmented in a training intensity-dependent manner and significantly correlated to the magnitude of sympathetic vasoconstrictor responsiveness. During acute exercise sympathetic outflow is increased however the vascular response to sympathetic stimulation is diminished and aids in the regulation of skeletal muscle blood flow; a physiologic phenomenon termed functional sympatholysis. The inhibition of sympathetic vasoconstriction during muscular contraction was augmented in a manner influenced by the intensity of ET through a nitric oxide-dependent mechanism. Given the increased resting sympathetic vasoconstrictor responsiveness and enhanced sympatholysis following training, it was hypothesized that ET may mediate these effects, in part, by an altered contribution of post-synaptic α2-adrenergic receptors to the regulation of sympathetic vasoconstriction. Exercise training significantly augmented the contribution of α2-adrenergic receptor to basal sympathetic vasoconstriction. During contraction the α2-adrenergic receptor was relatively resistant to inhibition. The ET induced increase in sympatholysis was mediated, in part, by the inhibition of the α1-adrenergic receptor through a nitric oxide-dependent mechanism. Collectively, these results highlight the integrated nature of ET mediated adaptations to sympathetic regulation of skeletal muscle vascular conductance and the plasticity of sympathetic regulation of skeletal muscle vascular conductance.

  • Subjects / Keywords
  • Graduation date
    2013-11
  • Type of Item
    Thesis
  • Degree
    Doctor of Philosophy
  • DOI
    https://doi.org/10.7939/R3QB9VH1S
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Doctoral
  • Department
    • Physical Education and Recreation
  • Supervisor / co-supervisor and their department(s)
    • Darren DeLorey, PhD Faculty of Physical Education and Recreation; Rehabilitation Medicine
  • Examining committee members and their departments
    • Michael Kennedy, PhD Faculty of Physical Education and Recreation
    • Paul Fadel, PhD School of Medicine Department of Pharmacology and Physiology University of Missouri
    • Robert Haennel, PhD Faculty of Rehabilitation Medicine
    • Gordon Bell, PhD Faculty of Physical Education and Recreation
    • Frances Plane, PhD Department of Pharmacology