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Skip to Search Results- 4Fliegel, Larry
- 4Sykes, Brian D.
- 2Lee, Brian L.
- 2Li, Xiuju J.
- 2Rainey, Jan K.
- 1Abdul Rahman, Siti Aishah
- 21Graduate and Postdoctoral Studies (GPS), Faculty of
- 21Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 4Biological Sciences, Department of
- 4Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 4Biochemistry, Department of
- 4Biochemistry, Department of/Journal Articles (Biochemistry)
- 8Department of Chemistry
- 3Faculty of Pharmacy and Pharmaceutical Sciences
- 2Department of Chemical and Materials Engineering
- 2Department of Oncology
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Biochemistry
- 4Vederas, John (Chemistry)
- 2Unsworth, Larry (Chemical and Materials Engineering)
- 1Derda, Ratmir
- 1Dr. Kaur, Kamaljit (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Kaur, Kamaljit (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
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Evaluation of Phosphatidylserine-Binding Peptides Radiolabeled with Fluorine 18 for in vivo Imaging of Apoptosis
DownloadSpring 2012
We currently do not have a clinical method to directly assess apoptosis induced by cancer therapies. Phosphatidylserine (PS) is an attractive target for imaging apoptosis since it is on the exterior of the apoptotic cells and PS externalization is an early marker of apoptosis. PS-binding peptides...
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Spring 2016
Biomining is an efficient way for improving mineral extraction and remediation processes. Using specific/targeted separation is a promising method to increase purification yield of minerals and metals at low cost. In traditional methods extraction and purification of the desired materials from...
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Light Responsive Linchpins for Accelerated Discovery of Light-Responsive Mono- and Bicyclic Peptide Ligands
DownloadSpring 2016
In this thesis I describe the development and application of light-responsive (LR) linchpins for efficient discovery of LR-peptides from genetically encoded peptide librar-ies. LR-linchpins have been used for dynamic control of the structure of peptides and their biochemical properties such as...
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1992
Forsyth, George W., Romancyia, D. A., Uwiera, Richard R. E., Wong, Jonathan P.
The B subunit of cholera toxin has been covalently attached to the surface of Uposomes made from a mixture of phosphatidylethanolamine, phosphati- dylcholine and cholesterol. Adenylate cydase inhibitors and chloride conduc- tance inhibitors were encapsulated within the liposomes. These...
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Oxidative stress mediates estrogen receptor independent killing and contributes to tamoxifen resistance
Download2016
Godbout, Roseline, Brindley, David N., McMullen, Todd, Mackey, John R., Benesch, Matthew, Mi, Si, Venkatraman, Ganesh, Liu, Rong-Zong, Curtis, Jonathan M., Tang, Xiaoyun, Bekele, Raie T.
Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...
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2006
RNA helicases function as molecular motors that rearrange RNA secondary structure, potentially performing roles in any cellular process involving RNA metabolism. Although RNA helicase association with a range of cellular functions is well documented, their importance in response to abiotic stress...
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RNA structural rearrangement via unwinding and annealing by the cyanobacterial RNA helicase, CrhR
Download2005
Owttrim, George W., Chamot, Danuta, Kujat-Choy, Sonya L., Colvin, Kimberley R.
Rearrangement of RNA secondary structure is crucial for numerous biological processes. RNA helicases participate in these rearrangements through the unwinding of duplex RNA. We report here that the redox-regulated cyanobacterial RNA helicase, CrhR, is a bona fide RNA helicase possessing both...