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Skip to Search Results- 18Alzheimer's disease
- 11Autophagy
- 3Amyloid precursor protein
- 2Amyloid beta
- 2Apoptosis
- 2Breast cancer
- 2Veldhoen, Richard
- 1Alsaleh, Nasser B
- 1Cochrane, Karen
- 1Davis, Christopher MJ
- 1Drouin, Shannon
- 1Fleck, Shelaine
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Zebrafish Targeted Mutagenesis to Unveil Normal Physiological Functions of, and Interactions between, Prion Protein (PrP) and Amyloid Precursor Protein (APP): Relevance to Alzheimer’s disease
DownloadSpring 2017
Much of the work on Prion Protein (PrPC) and Amyloid Precursor Protein (APP) biology has focused on the contributions of their misfolded forms or aggregated metabolites to prion diseases and Alzheimer’s disease, respectively. As subversion/partial loss of some normal functions are also likely...
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Use of autobiographical memory cues as cognitive support for episodic memory: Comparison of individuals with mild-stage Alzheimer's disease and healthy older adults
DownloadFall 2009
The purpose of the study was to examine the effectiveness of autobiographical memories to support the improvement of episodic memory (i.e., word recall) in patients with mild- stage Alzheimer’s Disease (AD) and healthy older adults. Participants included 20 healthy young-old adults (M Age =...
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Thermal response of amyloidogenic elements in cultured N2a cells: potential relevance to Alzheimer’s disease pathology
DownloadFall 2020
Alzheimer’s disease (AD) weighs a large burden on health care systems, families and caregiving networks around the world. It is the most common dementia afflicting elderly individuals, and causes many debilitating symptoms, including memory loss, mood swings and confusion which progress in...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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Fall 2017
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Spring 2016
Background: Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin (HTT) protein. Mutant huntingtin (mHTT) accumulates as toxic oligomers and aggregates inside the cell, when it is not removed efficiently by selective...
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Putative ante-mortem indicators of Alzheimer’s dementia: Analysis of fluid biomarker and neuroimaging studies
DownloadSpring 2019
Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...