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Skip to Search Results- 52Mass-spectrometry
- 12Affinity
- 8Metabolomics
- 6Electrospray ionization mass spectrometry
- 5Electrospray ionization
- 4Carbohydrates
- 41Graduate and Postdoctoral Studies (GPS), Faculty of
- 41Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 17Chemistry, Department of
- 17Chemistry, Department of/Journal Articles (Chemistry)
- 2Biological Sciences, Department of
- 2Biological Sciences, Department of/Journal Articles (Biological Sciences)
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2015
El-Hawiet, Amr, Klassen, John S., N. Kitova, Elena N.
The affinities of the most abundant oligosaccharides found in human milk for four bacterial exotoxins (from Vibrio cholerae and pathogenic Escherichia coli) were quantified for the first time. Association constants (Ka) for a library of 20 human milk oligosaccharides (HMOs) binding to Shiga toxin...
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Screening anti-cancer drugs against tubulin using catch-and-release electrospray ionization mass spectrometry
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Kitova, Elena N., Klassen, John S., Winter, Philip, Tuszynski, Jack A., Darestani, Reza R.
Tubulin, which is the building block of microtubules, plays an important role in cell division. This critical role makes tubulin an attractive target for the development of chemotherapeutic drugs to treat cancer. Currently, there is no general binding assay for tubulin–drug interactions. The...
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Screening anti-cancer drugs against tubulin using catch-and-release electrospray ionization mass spectrometry
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Kitova, Elena N., Klassen, John S., Winter, Philip, Tuszynski, Jack A., Darestani, Reza R.
Tubulin, which is the building block of microtubules, plays an important role in cell division. This critical role makes tubulin an attractive target for the development of chemotherapeutic drugs to treat cancer. Currently, there is no general binding assay for tubulin–drug interactions. The...
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Fall 2011
Liquid crystalline domains were observed in fractions of heavy petroleum. Through a combination of polarized light microscopy and Photoacoustic Infrared Spectroscopy, liquid crystals were shown to form on the exterior surface of their parent materials. Analysis of materials using Differential...
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Separation and characterization of polycyclic aromatic hydrocarbons and azaarenes using normal phase liquid chromatography and electrospray ionization mass spectrometry
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Normal phase liquid chromatography (NPLC) is widely used for separating petroleum into compound classes, such as polycyclic aromatic hydrocarbons (PAHs) and polar nitrogen containing compounds. The charge-transfer and hypercrosslinked polystyrene NPLC phases provide unique selectivities for PAHs....
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Spring 2017
A phenylarsenical, 3-nitro-4-hydroxyphenylarsonic acid (Roxarsone®, Rox), has been used extensively as a poultry feed additive for over 60 years. However, little is known about the concentrations of different arsenic species present in chicken meat as a consequence of feeding Rox to chickens....
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Structure and stability of carbohydrate-lipid interactions: Methylmannose polysaccharide-fatty acid complexes
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Klassen, John S., Siuda, Iwona, Renaud, Justin, Tieleman, D. Peter, Kitova, Elena N., Liu, Lan, Mayer, Paul M., Richards, Michele R., Lowary, Todd L.
We report a detailed study of the structure and stability of carbohydrate–lipid interactions. Complexes of a methylmannose polysaccharide (MMP) derivative and fatty acids (FAs) served as model systems. The dependence of solution affinities and gas-phase dissociation activation energies (Ea) on FA...
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Structure and stability of carbohydrate-lipid interactions: Methylmannose polysaccharide-fatty acid complexes
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Mayer, Paul M., Richards, Michele R., Lowary, Todd L., Renaud, Justin, Klassen, John S., Tieleman, D. Peter, Kitova, Elena N., Liu, Lan, Siuda, Iwona
We report a detailed study of the structure and stability of carbohydrate–lipid interactions. Complexes of a methylmannose polysaccharide (MMP) derivative and fatty acids (FAs) served as model systems. The dependence of solution affinities and gas-phase dissociation activation energies (Ea) on FA...
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Study of Non-Covalent Protein-Carbohydrate Interactions by Nanoelectrospray Ionization Mass Spectrometry and Surface Plasmon Resonance
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This thesis describes the application of electrospray ionization mass spectrometry (ESI-MS) techniques to identify and quantify antibody-antigen interactions in vitro. Also potential application of nanodiscs (ND) as membrane model in ESI-MS and surface plasmon resonance (SPR) spectroscopy has...