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Spring 2011
This thesis explores the capabilities of cationic polymers modified with lipids of different carbon chain length to deliver DNA molecules to primary cells and transformed cell lines. Our studies focus on two different polymers: polyethylenimine (PEI) and poly(L-lysine) (PLL). Firstly, PEI and PLL...
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Improving Measurements of the Mixing State and Mass Concentration of Particulate Emissions from Aircraft Engines
DownloadSpring 2016
This research is focused towards improving techniques used to measure particulate emissions from aircraft engines, on two fronts: first, to characterize and quantify the mixing state of particulate emissions; and second, to calibrate black carbon mass instruments with a traceable mass...
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Spring 2014
Gene delivery is an emerging therapy for treatment of many different diseases and conditions, with the first therapy recently approved for clinical use. This thesis investigates non-viral carriers for gene delivery for bone regeneration, with an emphasis on the mechanisms of plasmid DNA (pDNA)...
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Introduction of Competition in Regulated Markets: Analysis of Colombia’s Natural Gas Industry
DownloadFall 2016
This dissertation deals with the introduction of competition in regulated industries such as natural gas. The thesis focuses on the recently developed Colombian natural gas market and uses a more mature market, the deregulated gas market existing in the province of Alberta, Canada, as a benchmark...
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Spring 2019
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) are powerful stimulators of innate and adaptive immune responses, exerting their activity through the interaction with endolysosomal Toll-like receptor 9 (TLR9) expressed by antigen presenting cells (APCs). The strong...
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Spring 2012
The following thesis describes original studies assessing the gene delivery efficacy of novel non-viral carrier combinations. The first panel of non-viral carriers tested are termed AVPs (artificial viral particles), in reference to their structural similarity to enveloped viruses, and were...
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Spring 2018
The centrifugal particle mass analyzer (CPMA)-electrometer system has been proposed as an alternative method of calibration for devices that measure black carbon. This system is proposed to replace the current calibration standard of NIOSH 5040. The repeatability and intermediate precision of the...
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Fall 2020
Infectious respiratory diseases, caused by viruses and bacteria that attack the respiratory system, constitute a serious threat in public health around the world. Pathogens can be transmitted in the air though large droplets or aerosols. As aerosols can linger in the environment for a prolonged...
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Fall 2020
Sediment in storm sewers attracts increasing attentions in recent years due to two major issues including the sewer blockage and the environmental contamination. Pollutants attached to fine sediment surface may adversely affect aquatic life and natural water bodies. Excessive sediment deposition...
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Fall 2018
The goal of this thesis work was to develop an idealized adult nasal airway geometry capably of mimicking average regional nasal deposition of droplets emitted from pharmaceutical nasal sprays. The first part of this thesis examined regional deposition within the nose for nasal sprays over a...