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Spring 2014
A new aerosol particle classifier, the Aerodynamic Aerosol Classifier (AAC), is presented with some of its applications. The instrument uses a centrifugal force and sheath flow between two concentric rotating cylinders to produce a monodisperse aerosol classified by aerodynamic diameter. Since...
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Aquatic nanotoxicity testing: Insights at the biochemical, cellular, and whole animal levels
DownloadFall 2013
Aquatic organisms are susceptible to waterborne nanoparticles and there is only limited understanding of the mechanisms by which these emerging contaminants affect biological processes. The unique properties of nanomaterials necessitate evaluation of standard toxicity testing techniques to...
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Fall 2012
Glancing angle deposition (GLAD) is a physical vapour deposition (PVD) technique capable of fabricating highly porous thin films with controllable film morphology on the 10 nm length scale. The GLAD process is flexible and may be used on virtually any PVD-compatible material. This makes GLAD a...
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Fall 2010
The purpose of this project was to formulate, modify and evaluate nanoparticles for targeting asialoglycoprotein receptor found in large numbers exclusively on hepatocyte surfaces. Our goal is to increase the efficacy, reduce the side effects and the cost of the hydrophilic drugs administered to...
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Fall 2023
Background: The COVID-19 pandemic has shown us that our infection prevention and control (IPC) knowledge has some glaring gaps on what best ways to treat dental patients, leading to a flurry of research to understand the best mitigation strategies to reduce aerosols. One of these strategies...
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Fall 2017
Chicken feathers are byproduct of poultry industries and except some minor low end application, they are generally dumped into landfills. An effort has been made to utilize this by-product by transforming them into nano-reinforced bioplastics which is not only a solution to feather waste disposal...
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Spring 2011
The objective of this thesis is to design nanoparticle (NP)-based drug delivery systems suitable for treatment of bone diseases. Two types of nanocarriers, (1) polymer coated bovine serum albumin (BSA) NPs and (2) lipid based NPs (micelles and liposomes) were investigated. The BSA NPs were...
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Carbohydrate and Phosphorylcholine based Polymers Prepared by Reversible Addition-Fragmentation Chain Transfer Polymerization for Gene Therapy
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The study provides a comprehensive account on the development of novel synthetic carbohydrate and phosphorylcholine polymer based gene delivery vectors. Since the development and use of first non-viral vector for gene delivery applications, a wide range of polymers have been synthesized and...
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Cell-electronic Sensing of Cellular Responses and Toxicity Induced by Nanoparticles and Arsenic Species
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We demonstrate the development of a real-time cell analysis (RTCA) platform for studying nanoparticle- and arsenic-induced cytotoxicity with potential applications to risk assessment, environmental toxicity monitoring, and drug development. RTCA is an impedance-based in vitro detection system...
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Characterization of Aerosol Deposition in Children and Infants Using Idealized Extrathoracic Geometries
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This thesis describes a number of experimental studies performed with the common goal of characterizing pharmaceutical aerosol deposition in children and infants using idealized extrathoracic geometries. First, an in vitro study of the recently proposed Alberta Idealized Child Throat showed that...