Search
Skip to Search Results- 1Alberti, Devin
- 1Bandara, Nandika P.
- 1Brun, Miranda
- 1Bschaden, Benjamin Simon
- 1Chan, Brandon Y.H.
- 1Davies, Peter L.
- 19Graduate and Postdoctoral Studies (GPS), Faculty of
- 19Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
-
Spring 2020
The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...
-
Nanoengineered and Biomimetic Protein-derived Adhesives with Improved Adhesion Strength and Water Resistance
DownloadSpring 2017
The oilseed industry generates a great deal of meal after oil extraction. Soy meal has a number of value added applications while canola meal is used mainly as a low-value animal feed. There is a growing interest on value addition of meal beyond feed uses. Canola and soy meal contain ~ 33-37% and...
-
Fall 2019
Glioblastoma (GBM), classified as WHO grade IV astrocytoma, is the most common and lethal adult primary brain tumour. Despite recent advances in treatment, GBM prognosis remains largely unchanged with most patients succumbing to the disease within ~15 months of diagnosis. This dismal outcome can...
-
Fall 2015
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
-
Structure and function relationships of the binding of β- and ɑ-galactosylated oligosaccharides to K88 fimbriae of enterotoxigenic Escherichia coli
Download2018-01-01
Yan, Ya Lu, Gänzle, Michael G.
Chitosan-oligosaccharides (COS) are suitable acceptors for β-galactosidase, and galactosylated-COS prevent adhesion of enterotoxigenic Escherichia coli (ETEC) K88 to porcine erythrocytes. The structure and functional relationship of oligosaccharide binding to ETEC K88 fimbriae was investigated....
-
Structure and proteolytic susceptibility of the inhibitory C-terminal tail of cardiac troponin I
Download2019-01-01
Mahmud, Zabed, Zahran, Somaya, Liu, Philip B., Reiz, Bela, Chan, Brandon Y.H., Roczkowsky, Andrej, McCartney, Christian-Scott E., Davies, Peter L., Li, Liang, Schulz, Richard, Hwang, Peter M.
Background Cardiac troponin I (cTnI) has two flexible tails that control the cardiac cycle. The C-terminal tail, cTnI135-209, binds actin to shut off cardiac muscle contraction, whereas the competing calcium-dependent binding of the switch region, cTnI146-158, by cardiac troponin C (cTnC)...
-
The Influence of EPS Conditioning Films on Pseudomonas aeruginosa Adhesion to Solid Surfaces
DownloadFall 2010
Bacterial adhesion to inert surfaces in aquatic environments is highly dependent on the surface properties of the substratum, which could be altered significantly by the formation of conditioning films. The impacts of extracellular polymeric substances (EPS) and its several representative...
-
Theoretical and Experimental Investigation on the Use of Surface Acoustic Wave Sensors for Evaluating the Adhesion of SU-8 Thin Films
DownloadFall 2015
This research investigates the use of a SU-8/AlN/Si SAW sensor for evaluating the adhesion of SU-8 thin films. A theoretical model is developed to plot the wave dispersion profile for the SU-8/AlN/Si configuration. A spring interface model is utilized to represent the SU-8/AlN interface using a...
-
Fall 2020
In this thesis, the challenges involved with large-scale Fused Filament Fabrication (FFF) 3-dimensional (3D) printing is explored through an industrial application in which a cantilever chair is produced as a case study. The chair is designed in SOLIDWORKS® in which easy variability and complex...