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2015-07-31

Arantes, Adriano S., Tuggle, Christopher K., Guan, Le L., Bearson, Shawn M.D., Sun, Xu, Plastow, Graham S., Kommadath, Arun, Bao, Hua, Stothard, Paul, Liang, Guanxiang

To understand the role of miRNAs in regulating genes involved in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling of miRNAs and mRNAs from the whole blood of pigs upon Salmonella challenge was performed. A total of 62 miRNAs were differentially...

2015

Moore, Stephen S., Miller, Joshua M., Coltman, David W., Liao, Xiaoping, Stothard, Paul

Background Whole genome sequences (WGS) have proliferated as sequencing technology continues to improve and costs decline. While many WGS of model or domestic organisms have been produced, a growing number of non-model species are also being sequenced. In the absence of a reference, construction...

2009

Fernyhough, Melinda E., Hausman, Gary J., Guan, Leluo, Guridi, Maitea, Jiang, Zhihua, Dodson, Michael V., Chen, Jie

Clonal cultures of pig-derived mature adipocytes are capable of dedifferentiating and forming proliferative-competent progeny cells in vitro. Initial lipid processing, is different to that observed in cultures of beef-derived adipocytes. Mature pig adipocytes extrude lipid before proliferation,...

2020-12-01

Lipsit, Sean W. L., Wilkinson, James, Scruten, Erin, Facciuolo, Antonio, Denomy, Connor, Griebel, Philip J., Kusalik, Anthony, Plastow, Graham, Napper, Scott

Inter-individual variance in host immune responses following vaccination can result in failure to develop protective immunity leaving individuals at risk for infection in addition to compromising herd immunity. While developing more efficacious vaccines is one strategy to mitigate this problem,...

2011

Williams, John L., Moore, Stephen S., Almeida, Luciane M., Basu, Urmila, Guan, Leluo

Bovine spongiform encephalopathy (BSE) is a fatal disorder in cattle characterized by progressive neurodegeneration of the central nervous system. We investigated the molecular mechanisms involved in neurodegeneration during prion infection through the identification of genes that are...

2014

Jin, Weiwu, He, Maolong, Guan, Leluo, Romao, Josue M., McAllister, Tim

Background MicroRNAs (miRNAs) are small non-coding RNAs found to regulate several biological processes including adipogenesis. Understanding adipose tissue regulation is critical for beef cattle as fat is an important determinant of beef quality and nutrient value. This study analyzed the...

2011

Bergen, Werner G., Fernyhough, Melinda E., Hausman, Gary J., Dodson, Mike V., Du, Min, Mir, Priya S., Guan, Leluo, Jiang, Zhihua

Obesity and metabolic syndromes are examples whereby excess energy consumption and energy flux disruptions are causative agents of increased fatness. Because other, as yet elucidated, cellular factors may be involved and because potential treatments of these metabolic problems involve systemic...

2014

Liang, Guanxiang, Bao, Hua, Guan, Leluo, Griebel, Philip J., Stothard, Paul, McFadden, Thomas B., Malmuthuge, Nilusha

This study aimed to investigate the potential regulatory role of miRNAs in the development of gastrointestinal tract (GIT) during the early life of dairy calves. Rumen and small intestinal (mid-jejunum and ileum) tissue samples were collected from newborn (30 min after birth; n = 3), 7-day-old...

2013

Baron, Vern S., Ominski, Kim H., Guan, Leluo, Basarab, John A., Beauchemin, Karen A., Miller, Stephen P.

Genetic selection for residual feed intake (RFI) is an indirect approach for reducing enteric methane (CH4) emissions in beef and dairy cattle. RFI is moderately heritable (0.26 to 0.43), moderately repeatable across diets (0.33 to 0.67) and independent of body size and production, and when...

2015

Malecki, Irek A., Martin, Graeme B., Cozens, Greg, Hawken, Penelope A.R., Liang, Guanxiang, Guan, Yongjuan, Vercoe, Philip E., Guan, Le Luo

We tested whether reductions in spermatozoal quality induced by under-nutrition are associated with increased germ cell apoptosis and disrupted spermatogenesis, and whether these effects are mediated by small RNAs. Groups of 8 male sheep were fed for a 10% increase or 10% decrease in body mass...