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Skip to Search Results- 13Klassen, John S.
- 12Cairo, Christopher W.
- 11Kitova, Elena N.
- 10Li, Jun
- 7Eugenio, Luiz
- 7Zou, Chunxia
- 6Complexes
- 5neuraminidase
- 4Cholera-toxin binding
- 4Ionization mass-spectrometry
- 4Membranes
- 4Phospholipid-bilayer nanodiscs
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2018-01-05
Guo, Tianlin, Datwyler, Philipp, Demina, Ekaterina, Richards, Michele R, Ge, Peng, Zou, Chunxia, Zheng, Ruixiang Blake, Fougerat, Anne, Pshezhetsky, Alexey V, Ernst, Beat, Cairo, Christopher W.
Human neuraminidases (NEU) are associated with human diseases including cancer, atherosclerosis, and diabetes. To obtain small molecule inhibitors as research tools for the study of their biological functions, we designed a library of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues...
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Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile
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Ng, Kenneth K. S., Tanha, Jamshid, Kitova, Elena N., Eugenio, Luiz, Murase, Tomohiko, Klassen, John S., Hussack, Greg, Schorr, Melissa
Clostridium difficile infection is a serious and highly prevalent nosocomial disease in which the two large, Rho-glucosylating toxins TcdA and TcdB are the main virulence factors. We report for the first time crystal structures revealing how neutralizing and non-neutralizing single-domain...
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2018-05-24
Hunter, Carmanah D, Guo, Tianlin, Daskhan, Gour, Richards, Michele R, Cairo, Christopher W.
The plasma membrane of cells contains a diverse array of lipids that provide important structural and biological features. Glycolipids are typically a minor component of the cell membrane and consist primarily of glycosphingolipids (GSLs). GSLs in vertebrates contain a multifarious assortment of...