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Skip to Search Results- 6Ban, Matthew R.
- 6Hegele, Robert A.
- 6Young, T. Kue
- 5Bjerregaard, Peter
- 3Connelly, Philip W.
- 3Huff, Murray W.
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Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
Download2007-12-20
Pollex, Rebecca L., Ban, Matthew R., Young, T. Kue, Bjerregaard, Peter, Anand, Sonia S., Yusuf, Salim, Zinman, Bernard, Harris, Stewart B., Hanley, Anthony J. G., Connelly, Philip W., Huff, Murray W., Hegele, Robert A.
"Background: Common polymorphisms in the promoter of the APOC3 gene have been associated with hypertriglyceridemia and may impact on phenotypic expression of the metabolic syndrome (MetS). The rs7566605 marker, located near the INSIG2 gene, has been found to be associated with obesity, making it...
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Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
Download2008-03-13
Al-Attar, Salam A., Pollex, Rebecca L., Ban, Matthew R., Young, T. Kue, Bjerregaard, Peter, Anand, Sonia S., Yusuf, Salim, Zinman, Bernard, Harris, Stewart B., Hanley, Anthony J. G., Connelly, Philip W., Huff, Murray W., Hegele, Robert A.
"Background: The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in...
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Common Low-Density Lipoprotein Receptor p.G116S Variant Has a Large Effect on Plasma Low-Density Lipoprotein Cholesterol in Circumpolar Inuit Populations
Download2014-11-20
Dubé, Joseph B., Wang, Jian, Cao, Henian, McIntyre, Adam D., Johansen, Christopher T., Hopkins, Scarlett E., Stringer, Randa, Hosseinzadeh, Siyavash, Kennedy, Brooke A., Ban, Matthew R., Young, T. Kue, Connelly, Philip W., Dewailly, Eric, Bjerregaard, Peter, Boyer, Bert B., Hegele, Robert A.
"Background: Inuit are considered to be vulnerable to cardiovascular disease because their lifestyles are becoming more Westernized. During sequence analysis of Inuit individuals at extremes of lipid traits, we identified 2 nonsynonymous variants in low-density lipoprotein receptor (LDLR), namely...
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Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in Greenlanders
Download2007-12-01
Lahiry, Piya, Ban, Matthew R., Pollex, Rebecca L., Sawyez, Cynthia G., Huff, Murray W., Young, T. Kue, Bjerregaard, Peter, Hegele, Robert A.
"Objectives: We undertook studies of the association between common genomic variations in APOC3, APOA5, APOE and PON1 genes and variation in biochemical phenotypes in a sample of Greenlanders. Study Design: Genetic association study of quantitative lipoprotein traits. Methods: In a sample of...
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Promoter Polymorphism in PCK1 (Phosphoenolpyruvate Carboxykinase Gene) Associated with Type 2 Diabetes Mellitus
Download2004-02-01
Cao, Henian, van der Veer, Eric, Ban, Matthew R., Hanley, Anthony J.G., Zinman, Bernard, Harris, S. B., Young, T. Kue, Pickering, J. Geoffrey, Hegele, Robert A.
"We sequenced the promoter and coding regions of PCK1 encoding cytosolic phosphoenolpyruvate carboxykinase from genomic DNA of subjects with type 2 diabetes mellitus (DM). We found nine single nucleotide polymorphisms (SNPs) that were present with varying allele frequencies and pairwise linkage...
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Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit
Download2012-03-18
Johansen, Christopher T., Gallinger, Zane R., Wang, Jian, Ban, Matthew R., Young, T. Kue, Bjerregaard, Peter, Hegele, Robert A.
"Objectives: To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit. Study design: Candidate gene association study of discrete and quantitative traits related to...