Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample

• Author(s) / Creator(s)

  • Pollex, Rebecca L.
  • Ban, Matthew R.
  • Young, T. Kue
  • Bjerregaard, Peter
  • Anand, Sonia S.
  • Yusuf, Salim
  • Zinman, Bernard
  • Harris, Stewart B.
  • Hanley, Anthony J. G.
  • Connelly, Philip W.
  • Huff, Murray W.
  • Hegele, Robert A.

• "Background: Common polymorphisms in the promoter of the APOC3 gene have been associated with hypertriglyceridemia and may impact on phenotypic expression of the metabolic syndrome (MetS). The rs7566605 marker, located near the INSIG2 gene, has been found to be associated with obesity, making it also a potential genetic determinant for MetS. The objective of this study is to examine the APOC3 -455T>C and the INSIG2 rs7566605 polymorphisms as potential genetic determinants for MetS in a multi-ethnic sample. Methods: Subjects were genotyped for both the APOC3 -455T>C and INSIG2 rs7566605 polymorphisms, and classified for the presence or absence of MetS (NCEP ATP III and IDF definitions). The total study population included 2675 subjects (≥18 years of age) from six different geographical ancestries." (as cited in abstract)

• Date created

  2007-12-20

• Subjects / Keywords

  • Waist circumference
  • Cholesteryl ester transfer protein
  • Allele carrier
  • Waist circumference measurement
  • Cholesteryl ester transfer protein activity
  • Canada
  • Greenland
  • Nunavut
  • Ontario

• Type of Item

  Article (Published)

• DOI

  https://doi.org/10.7939/r3-yjq2-8686

• License

  Attribution 4.0 International