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Skip to Search Results- 12Phosphatidylcholine
- 2Choline
- 2Phospholipid Metabolism
- 2Triacylglycerol
- 1Acyl editing
- 1Adipose Tissue
- 7Graduate and Postdoctoral Studies (GPS), Faculty of
- 7Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 5Agricultural, Food and Nutritional Science, Department of
- 5Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Jacobs, Rene (Agricultural, Food and Nutritional Science)
- 2Vance, Dennis E. (Biochemistry)
- 1Field, Catherine (Agricultural, Food and Nutritional Science)
- 1Temelli, Feral (Agricultural, Food and Nutritional Science)
- 1Vance, Dennis (Biochemistry)
- 1Weselake, Randall, J (Department of Agricultural, Food, and Nutritional Science)
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2020-03-01
Tian, Bo, Sun, Meijuan, Jayawardana, Kethmi, Wu, Ding, Chen, Guanqun
Castor oil contains approximately 90% ricinoleic acid (RA) which is stored mainly in the form of tri‐ricinoleic acid containing triacylglycerols (TAG). Ricinoleate is synthesized from oleate (18:1n‐9) esterified to the sn‐2 position of phosphatidylcholine (PtdCho) catalyzed by...
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Characterization of Phosphatidylcholine Metabolism in Mouse Hepatocytes after Hepatectomy and in Primary Human Hepatocytes
DownloadSpring 2012
Phosphatidylcholine (PC) is the major component of mammalian membranes and the induction of PC biosynthesis has been shown to be an essential step in cell proliferation in various cell lines. In the liver, PC biosynthesis is regulated by two pathways: the CDP-choline and the...
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Fall 2016
Choline is an essential micronutrient with increased requirements during pregnancy and lactation due to a high demand by the developing fetus and infant. Animal studies have demonstrated that choline is essential for brain development, and as a component of all cell membranes it is hypothesized...
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Functional Characterization of Plant Patatin-like Phospholipase A III in Transgenic Arabidopsis thaliana Producing 18 Carbon Hydroxy Fatty Acids
DownloadFall 2016
Hydroxy fatty acid (HFA)-enriched oils are valuable in many oleo-chemical industries. The major natural source of HFA, however, is castor (Ricinus communis) seed, which is poisonous to human beings and animals. Although over-expressing a castor OLEATE 12-HYDROXYLASE (RcFAH12) in Arabiodpsis...
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Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
Download2010
Kuo, Ming-Shang, Dyck, Jason R. B., Sletten, Torunn, Proctor, Spencer D., Jacobs, René L., Lingrell, Susanne, Cao, Guoqing, Peake, David A., Kennedy, Brian P., Zhao, Yang, Vance, Dennis E., Koonen, Debby P. Y., Su, Brian
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study investigates whether or not hepatic...
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Spring 2013
Egg yolk contains approximately 10% (w/w) phospholipids (PL), of which about 70% is phosphatidylcholine (PC). Conventional methods of PL extraction from egg yolk involve using hazardous organic solvents. Supercritical carbon dioxide (SC-CO2), as a "green" solvent, had been applied for the...
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In vivo and in vitro evidence for biochemical coupling of reactions catalyzed by lysophosphatidylcholine acyltransferase and diacyglycerol acyltransferase
Download2015
Greer, Michael S., Pan, Xue, Weselake, Randall J., Chen, Guanqun, Zou, Jitao, Caldo, Kristian Mark P., Kazachkov, Michael
Seed oils of flax (Linum usitatissimum L.) and many other plant species contain substantial amounts of polyunsaturated fatty acids (PUFAs). Phosphatidylcholine (PC) is the major site for PUFA synthesis. The exact mechanisms of how these PUFAs are channeled from PC into triacylglycerol (TAG) needs...
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Insights into the role of CTP:phosphocholine cytidylyltransferase-alpha in hepatic lipid metabolism and cellular integrity
DownloadFall 2011
Lower levels of hepatic phosphatidylcholine (PC) are suggested to play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). Mice lacking hepatic CTP:phosphocholine cytidylyltransferase-α (LCTα-/-), the regulatory enzyme in the CDP-choline pathway for PC biosynthesis, were fed a...
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Insights into the Transcriptional Regulation and Physiological Importance of Phosphatidylethanolamine N-Methyltransferase
DownloadSpring 2010
Phosphatidylcholine (PC) is made in all nucleated mammalian cells via the CDP-choline pathway. Another major pathway for PC biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). We have identified 3T3-L1 adipocytes as a cell culture model that expresses PEMT...
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Plant acyl-CoA:lysophosphatidylcholine acyltransferases (LPCATs) have different specificities in their forward and reverse reactions
Download2013
Heinz, Ernst, Zhou, Xue-Rong, Banas, Antoni, Green, Allan, Jasieniecka, Katarzyna, Weselake, Randall, Smith, Mark A., Stymne, Sten, Bayon, Shen, Zou, Jitao, Lager, Ida, Dyer, John M., Shockey, Jay M., Yilmaz, Jenny L., Wang, Peng, Kazachkov, Michael
Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT) enzymes have central roles in acyl editing of phosphatidylcholine (PC). Plant LPCAT genes were expressed in yeast and characterized biochemically in microsomal preparations of the cells. Specificities for different acyl-CoAs were similar...