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Bubble Pressure Measurement and Modeling for n-Alkane + Aromatic Hydrocarbon Binary Mixtures
DownloadFall 2017
Commonly-used cubic equations of state (EOS) over predict the bubble point pressures (BPPs) for binary long-chain n-alkane + aromatic mixtures and frequently predict the incorrect phase diagram type. In this work, BPPs for 15 representative n-alkane + aromatic hydrocarbon binary mixtures were...
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2002-01-01
Li, Xiuju J., Alvarez, Bernando, Casey, Joseph R., Reithmeier, Reinhart A. F., Fliegel, Larry
We examined the ability of carbonic anhydrase II to bind to and affect the transport efficiency of the NHE1 isoform of the mammalian Na+/H+ exchanger. The C-terminal region of NHE1 was expressed in Escherichia coli fused with an N-terminal glutathionineS-transferase or with a C-terminal...
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2009
Grant, Jason, Stothard, Paul, Moore, Stephen S., Guan, Leluo, Jin, Weiwu
Background MicroRNAs (miRNAs) are a family of ~22 nucleotide small RNA molecules which regulate gene expression by fully or partially binding to their complementary sequences in mRNAs or promoters. A large number of miRNAs and their expression patterns have been reported in human, mouse and rat....
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Classifying Crystal Structures of Binary Compounds AB through Cluster Resolution Feature Selection and Support Vector Machine Analysis
Download2016
Adutwum, Lawrence A. , Harynuk, James, Mar, Arthur, Oliynyk, Anton O.
Partial least-squares discriminant analysis (PLS-DA) and support vector machine (SVM) techniques were applied to develop a crystal structure predictor for binary AB compounds. Models were trained and validated on the basis of the classification of 706 AB compounds adopting the seven most common...
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Spring 2012
Accurately identifying strand residues (beta-residues) from protein sequences aids prediction and analysis of numerous structural and functional aspects of proteins. This thesis is focused on improving sequence-based prediction of strand residues and strands, which in turn would lead to better...
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Computational support systems for prediction and characterization of protein crystallization outcomes
DownloadFall 2013
Analysis of protein structures may reveal their function, regulation and interactions. Almost 90% of the known protein structures were solved using X-ray crystallography; however, many more structures remain unsolved. Protein Structure Initiative (PSI) project was created to speed up structure...
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CS23D: A web server for rapid protein structure generation using NMR chemical shifts and sequence data
Download2008
Wishart, D.S., Berjanskii, M., Arndt, D., Lin, G., Tang, P., Zhou, J.
CS23D (chemical shift to 3D structure) is a web server for rapidly generating accurate 3D protein structures using only assigned nuclear magnetic resonance (NMR) chemical shifts and sequence data as input. Unlike conventional NMR methods, CS23D requires no NOE and/or J-coupling data to perform...
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Development of an assay for the identification of campylobacter bacteriophage receptor binding proteins
Development of an assay for the identification of campylobacter bacteriophage receptor binding proteins
Download2012-10-25
Bacterial viruses (phages) are ubiquitous in the environment and are believed to target every bacterial species. Phages utilize receptor binding proteins (RBPs) to bind specifically to their host cell surface. The Campylobacter jejuni phage NCTC 12673 RBP and its capsular polysaccharide (CPS)...
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Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas
Download2014
McBride, Ryan, Fokin, Valery V., He, Yuan, Macauley, Matthew S., Paulson, James C. , Arlian, Britni M., Rillahan, Cory D., Rangarajan, Janani, Schwartz, Erik
The siglec family of sialic acid-binding proteins are endocytic immune cell receptors that are recognized as potential targets for cell directed therapies. CD33 and CD22 are prototypical members and are validated candidates for targeting acute myeloid leukaemia and non-Hodgkin's lymphomas due to...
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2006
Berlyn, M.K., Plunkett, G., Wishart, D.S., Nori, H., Riley, M., Rudd, K.E., Glasner, J.D., Arnaud, M.B., Abe, T., Thomson, N.R., Wanner, B.L., Pernas, N.T., Blattner, F.R., Serres, M.H., Thomas, G.H., Horiuchi, T., Kosuge, T., Keseler, I.M., Chaudhuri, R.R.
The goal of this group project has been to coordinate and bring up-to-date information on all genes of Escherichia coli K-12. Annotation of the genome of an organism entails identification of genes, the boundaries of genes in terms of precise start and end sites, and description of the gene...